6we5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6we5" [edit=sysop:move=sysop])
Current revision (14:22, 18 October 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='6we5' size='340' side='right'caption='[[6we5]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='6we5' size='340' side='right'caption='[[6we5]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6we5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WE5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WE5 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6we5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydia_trachomatis_D/UW-3/CX Chlamydia trachomatis D/UW-3/CX]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WE5 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inorganic_diphosphatase Inorganic diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.1 3.6.1.1] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6we5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6we5 OCA], [http://pdbe.org/6we5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6we5 RCSB], [http://www.ebi.ac.uk/pdbsum/6we5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6we5 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6we5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6we5 OCA], [https://pdbe.org/6we5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6we5 RCSB], [https://www.ebi.ac.uk/pdbsum/6we5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6we5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/IPYR_CHLTR IPYR_CHLTR]] Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
+
[https://www.uniprot.org/uniprot/IPYR_CHLTR IPYR_CHLTR] Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections globally and is one of the most commonly reported infections in the United States. There is a need to develop new therapeutics due to drug resistance and the failure of current treatments to clear persistent infections. Structures of potential C. trachomatis rational drug-discovery targets, including C. trachomatis inorganic pyrophosphatase (CtPPase), have been determined by the Seattle Structural Genomics Center for Infectious Disease. Inorganic pyrophosphatase hydrolyzes inorganic pyrophosphate during metabolism. Furthermore, bacterial inorganic pyrophosphatases have shown promise for therapeutic discovery. Here, a 2.2 A resolution X-ray structure of CtPPase is reported. The crystal structure of CtPPase reveals shared structural features that may facilitate the repurposing of inhibitors identified for bacterial inorganic pyrophosphatases as starting points for new therapeutics for C. trachomatis.
 +
 
 +
Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx.,Maddy J, Staker BL, Subramanian S, Abendroth J, Edwards TE, Myler PJ, Hybiske K, Asojo OA Acta Crystallogr F Struct Biol Commun. 2022 Mar 1;78(Pt 3):135-142. doi:, 10.1107/S2053230X22002138. Epub 2022 Feb 28. PMID:35234139<ref>PMID:35234139</ref>
 +
 
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 6we5" style="background-color:#fffaf0;"></div>
 +
 
 +
==See Also==
 +
*[[Inorganic pyrophosphatase 3D structures|Inorganic pyrophosphatase 3D structures]]
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Inorganic diphosphatase]]
+
[[Category: Chlamydia trachomatis D/UW-3/CX]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Structural genomic]]
 
-
[[Category: Hydrolase]]
 
-
[[Category: National institute of allergy and infectious disease]]
 
-
[[Category: Niaid]]
 
-
[[Category: Pyrophosphate phospho-hydrolase]]
 
-
[[Category: Sexually transmitted infection]]
 
-
[[Category: Ssgcid]]
 
-
[[Category: Std]]
 
-
[[Category: Sti]]
 

Current revision

Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx

PDB ID 6we5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6we5"
Personal tools