6klh

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<StructureSection load='6klh' size='340' side='right'caption='[[6klh]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<StructureSection load='6klh' size='340' side='right'caption='[[6klh]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6klh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Machu Machu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KLH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KLH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6klh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammarenavirus_machupoense Mammarenavirus machupoense] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KLH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KLH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6klh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6klh OCA], [http://pdbe.org/6klh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6klh RCSB], [http://www.ebi.ac.uk/pdbsum/6klh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6klh ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6klh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6klh OCA], [https://pdbe.org/6klh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6klh RCSB], [https://www.ebi.ac.uk/pdbsum/6klh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6klh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q6IVU0_MACHU Q6IVU0_MACHU]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.[HAMAP-Rule:MF_04086][PIRNR:PIRNR000836]
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[https://www.uniprot.org/uniprot/Q6IVU0_MACHU Q6IVU0_MACHU] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.[HAMAP-Rule:MF_04086][PIRNR:PIRNR000836]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6klh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6klh" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Machu]]
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[[Category: Mammarenavirus machupoense]]
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[[Category: Gao, G F]]
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[[Category: Synthetic construct]]
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[[Category: Jing, J]]
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[[Category: Gao GF]]
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[[Category: Peng, Q]]
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[[Category: Jing J]]
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[[Category: Peng, R]]
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[[Category: Peng Q]]
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[[Category: Shi, Y]]
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[[Category: Peng R]]
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[[Category: Xu, X]]
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[[Category: Shi Y]]
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[[Category: Polymerase]]
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[[Category: Xu X]]
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[[Category: Rna virus]]
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[[Category: Viral protein-rna complex]]
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Current revision

Dimeric structure of Machupo virus polymerase bound to vRNA promoter

PDB ID 6klh

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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