6ky6

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==Crystal struture of a thermostable aldo-keto reductase Tm1743 in complexs with inhibitor epalrestat in space group P3221==
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==Crystal structure of a thermostable aldo-keto reductase Tm1743 in complexs with inhibitor epalrestat in space group P3221cc==
<StructureSection load='6ky6' size='340' side='right'caption='[[6ky6]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
<StructureSection load='6ky6' size='340' side='right'caption='[[6ky6]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ky6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KY6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KY6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ky6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KY6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPR:{5-[(2E)-2-METHYL-3-PHENYLPROP-2-EN-1-YLIDENE]-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL}ACETIC+ACID'>EPR</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6kiy|6kiy]], [[6kik|6kik]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPR:{5-[(2E)-2-METHYL-3-PHENYLPROP-2-EN-1-YLIDENE]-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL}ACETIC+ACID'>EPR</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TM_1743, Tmari_1751 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ky6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ky6 OCA], [https://pdbe.org/6ky6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ky6 RCSB], [https://www.ebi.ac.uk/pdbsum/6ky6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ky6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ky6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ky6 OCA], [http://pdbe.org/6ky6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ky6 RCSB], [http://www.ebi.ac.uk/pdbsum/6ky6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ky6 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9X265_THEMA Q9X265_THEMA]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thema]]
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[[Category: Thermotoga maritima MSB8]]
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[[Category: Liu, X M]]
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[[Category: Liu XM]]
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[[Category: Min, Z Z]]
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[[Category: Min ZZ]]
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[[Category: Tang, W R]]
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[[Category: Tang WR]]
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[[Category: Wang, C]]
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[[Category: Wang C]]
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[[Category: Zhang, C Y]]
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[[Category: Zhang CY]]
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[[Category: Aldo-ketone reductase]]
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[[Category: Competitive inhibitor]]
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[[Category: Epalrestat]]
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[[Category: Oxidoreductase]]
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[[Category: Tolrestat]]
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Current revision

Crystal structure of a thermostable aldo-keto reductase Tm1743 in complexs with inhibitor epalrestat in space group P3221cc

PDB ID 6ky6

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