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6p0p

From Proteopedia

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Current revision (07:20, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6p0p' size='340' side='right'caption='[[6p0p]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='6p0p' size='340' side='right'caption='[[6p0p]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6p0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P0P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6P0P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6p0p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P0P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P0P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Y35:(3-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}[1,1-biphenyl]-3-yl){4-[3-(aminomethyl)phenyl]piperidin-1-yl}[3,4-di(hydroxy-kappaO)phenyl]methanonato(2-)hydroxyborate(1-)'>Y35</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TPSAB1, TPS1, TPS2, TPSB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Y35:(3-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}[1,1-biphenyl]-3-yl){4-[3-(aminomethyl)phenyl]piperidin-1-yl}[3,4-di(hydroxy-kappaO)phenyl]methanonato(2-)hydroxyborate(1-)'>Y35</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p0p OCA], [https://pdbe.org/6p0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p0p RCSB], [https://www.ebi.ac.uk/pdbsum/6p0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p0p ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6p0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p0p OCA], [http://pdbe.org/6p0p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p0p RCSB], [http://www.ebi.ac.uk/pdbsum/6p0p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p0p ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).
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[https://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6p0p" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6p0p" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tryptase|Tryptase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Tryptase]]
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[[Category: Arnold LD]]
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[[Category: Arnold, L D]]
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[[Category: Barany F]]
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[[Category: Barany, F]]
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[[Category: Bergstrom DE]]
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[[Category: Bergstrom, D E]]
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[[Category: Feinberg PB]]
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[[Category: Feinberg, P B]]
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[[Category: Foreman KW]]
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[[Category: Foreman, K W]]
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[[Category: Giardina SF]]
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[[Category: Giardina, S F]]
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[[Category: Pingle MR]]
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[[Category: Pingle, M R]]
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[[Category: Werner DS]]
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[[Category: Werner, D S]]
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[[Category: Bivalent inhibitor]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protease inhibitor]]
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Current revision

Human beta-tryptase co-crystal structure with 5-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}-2-(3'-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}-[1,1'-biphenyl]-3-yl)-2-hydroxy-2H-1,3,2-benzodioxaborol-2-uide

PDB ID 6p0p

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OCA

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