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| | <StructureSection load='5dcl' size='340' side='right'caption='[[5dcl]], [[Resolution|resolution]] 1.41Å' scene=''> | | <StructureSection load='5dcl' size='340' side='right'caption='[[5dcl]], [[Resolution|resolution]] 1.41Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5dcl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptoccocus_de_la_mammite"_nocard_and_mollereau_1887 "streptoccocus de la mammite" nocard and mollereau 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DCL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DCL FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5dcl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_agalactiae Streptococcus agalactiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DCL FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.41Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DK41_05180, EN72_05470 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1311 "Streptoccocus de la mammite" Nocard and Mollereau 1887])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dcl OCA], [http://pdbe.org/5dcl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dcl RCSB], [http://www.ebi.ac.uk/pdbsum/5dcl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dcl ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dcl OCA], [https://pdbe.org/5dcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dcl RCSB], [https://www.ebi.ac.uk/pdbsum/5dcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dcl ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/X5JZS1_STRAG X5JZS1_STRAG] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Streptoccocus de la mammite nocard and mollereau 1887]] | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Hoeppner, A]] | + | [[Category: Streptococcus agalactiae]] |
| - | [[Category: Khosa, S]] | + | [[Category: Hoeppner A]] |
| - | [[Category: Kleinschrodt, D]] | + | [[Category: Khosa S]] |
| - | [[Category: Smits, S H]]
| + | [[Category: Kleinschrodt D]] |
| - | [[Category: Antimicrobial peptide]] | + | [[Category: Smits SH]] |
| - | [[Category: Lantibiotic]] | + | |
| - | [[Category: Nisin]]
| + | |
| - | [[Category: Regulation]]
| + | |
| - | [[Category: Resistance]]
| + | |
| - | [[Category: Signaling protein]]
| + | |
| - | [[Category: Two component system]]
| + | |
| Structural highlights
Function
X5JZS1_STRAG
Publication Abstract from PubMed
Lantibiotics are antimicrobial peptides produced by Gram-positive bacteria. Interestingly, several clinically relevant and human pathogenic strains are inherently resistant towards lantibiotics. The expression of the genes responsible for lantibiotic resistance is regulated by a specific two-component system consisting of a histidine kinase and a response regulator. Here, we focused on a response regulator involved in lantibiotic resistance, NsrR from Streptococcus agalactiae, and determined the crystal structures of its N-terminal receiver domain and C-terminal DNA-binding effector domain. The C-terminal domain exhibits a fold that classifies NsrR as a member of the OmpR/PhoB subfamily of regulators. Amino acids involved in phosphorylation, dimerization, and DNA-binding were identified and demonstrated to be conserved in lantibiotic resistance regulators. Finally, a model of the full-length NsrR in the active and inactive state provides insights into protein dimerization and DNA-binding.
Structure of the Response Regulator NsrR from Streptococcus agalactiae, Which Is Involved in Lantibiotic Resistance.,Khosa S, Hoeppner A, Gohlke H, Schmitt L, Smits SH PLoS One. 2016 Mar 1;11(3):e0149903. doi: 10.1371/journal.pone.0149903., eCollection 2016. PMID:26930060[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Khosa S, Hoeppner A, Gohlke H, Schmitt L, Smits SH. Structure of the Response Regulator NsrR from Streptococcus agalactiae, Which Is Involved in Lantibiotic Resistance. PLoS One. 2016 Mar 1;11(3):e0149903. doi: 10.1371/journal.pone.0149903., eCollection 2016. PMID:26930060 doi:http://dx.doi.org/10.1371/journal.pone.0149903
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