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4cbf

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<SX load='4cbf' size='340' side='right' viewer='molstar' caption='[[4cbf]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
<SX load='4cbf' size='340' side='right' viewer='molstar' caption='[[4cbf]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cbf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4CBF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cbf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [https://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CBF FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cau|4cau]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4cbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cbf OCA], [http://pdbe.org/4cbf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cbf RCSB], [http://www.ebi.ac.uk/pdbsum/4cbf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cbf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cbf OCA], [https://pdbe.org/4cbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cbf RCSB], [https://www.ebi.ac.uk/pdbsum/4cbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cbf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/E0WXI2_9FLAV E0WXI2_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774]
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[https://www.uniprot.org/uniprot/E0WXI2_9FLAV E0WXI2_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
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[[Category: Dengue virus 4]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chew, P L]]
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[[Category: Chew PL]]
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[[Category: Kostyuchenko, V A]]
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[[Category: Kostyuchenko VA]]
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[[Category: Lok, S M]]
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[[Category: Lok SM]]
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[[Category: Ng, T S]]
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[[Category: Ng TS]]
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[[Category: Flavivirus]]
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[[Category: Virus]]
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Current revision

Near-atomic resolution cryo-EM structure of Dengue serotype 4 virus

4cbf, resolution 4.10Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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