This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5a42
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 3: | Line 3: | ||
<SX load='5a42' size='340' side='right' viewer='molstar' caption='[[5a42]], [[Resolution|resolution]] 16.00Å' scene=''> | <SX load='5a42' size='340' side='right' viewer='molstar' caption='[[5a42]], [[Resolution|resolution]] 16.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5a42]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5a42]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A42 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 16Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a42 OCA], [https://pdbe.org/5a42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a42 RCSB], [https://www.ebi.ac.uk/pdbsum/5a42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a42 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A2MG_ECOLI A2MG_ECOLI] Protects the bacterial cell from host peptidases (PubMed:18697741, PubMed:26143919, PubMed:26100869). Acts by a 'trapping' mechanism. Cleavage of the bait-region domain by host peptidases leads to a global conformational change, which results in entrapment of the host peptidase and activation of the thioester bond that covalently binds the attacking host peptidase (PubMed:26143919, PubMed:26100869). Trapped peptidases are still active except against very large substrates (PubMed:26100869). May protect the entire periplam, including the lipoproteins anchored to the periplasmic side of the outer membrane, against intruding endopeptidases (PubMed:26100869).<ref>PMID:18697741</ref> <ref>PMID:26100869</ref> <ref>PMID:26143919</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 19: | Line 22: | ||
__TOC__ | __TOC__ | ||
</SX> | </SX> | ||
| - | [[Category: | + | [[Category: Escherichia coli K-12]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arede | + | [[Category: Arede P]] |
| - | [[Category: Caston | + | [[Category: Caston JR]] |
| - | [[Category: Duquerroy | + | [[Category: Duquerroy S]] |
| - | [[Category: Garcia-Ferrer | + | [[Category: Garcia-Ferrer I]] |
| - | [[Category: Gomez-Blanco | + | [[Category: Gomez-Blanco J]] |
| - | [[Category: Gomis-Ruth | + | [[Category: Gomis-Ruth FX]] |
| - | [[Category: Goulas | + | [[Category: Goulas T]] |
| - | [[Category: Luque | + | [[Category: Luque D]] |
| - | + | ||
| - | + | ||
Current revision
Cryo-EM single particle 3D reconstruction of the native conformation of E. coli alpha-2-macroglobulin (ECAM)
| |||||||||
