5fuu

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==Ectodomain of cleaved wild type JR-FL EnvdCT trimer in complex with PGT151 Fab==
==Ectodomain of cleaved wild type JR-FL EnvdCT trimer in complex with PGT151 Fab==
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<SX load='5fuu' size='340' side='right' viewer='molstar' caption='[[5fuu]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
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<SX load='5fuu' size='340' side='right' viewer='molstar' caption='[[5fuu]], [[Resolution|resolution]] 4.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fuu]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FUU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fuu]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FUU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.19&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fuu OCA], [http://pdbe.org/5fuu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fuu RCSB], [http://www.ebi.ac.uk/pdbsum/5fuu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fuu ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fuu OCA], [https://pdbe.org/5fuu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fuu RCSB], [https://www.ebi.ac.uk/pdbsum/5fuu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fuu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q75760_9HIV1 Q75760_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
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[https://www.uniprot.org/uniprot/Q6BC19_9HIV1 Q6BC19_9HIV1]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Homo sapiens]]
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[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lee, J H]]
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[[Category: Lee JH]]
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[[Category: Ward, A B]]
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[[Category: Ward AB]]
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[[Category: Broadly neutralizing antibody]]
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[[Category: Env]]
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[[Category: Hiv-1]]
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[[Category: Pgt151]]
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[[Category: Viral protein]]
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Current revision

Ectodomain of cleaved wild type JR-FL EnvdCT trimer in complex with PGT151 Fab

5fuu, resolution 4.19Å

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OCA

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