5ng5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:54, 15 November 2023) (edit) (undo)
 
Line 3: Line 3:
<SX load='5ng5' size='340' side='right' viewer='molstar' caption='[[5ng5]], [[Resolution|resolution]] 6.50&Aring;' scene=''>
<SX load='5ng5' size='340' side='right' viewer='molstar' caption='[[5ng5]], [[Resolution|resolution]] 6.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5ng5]] is a 15 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NG5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NG5 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5ng5]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NG5 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5QF:6-[2-(3,4-DIMETHOXYPHENYL)ETHYLSULFANYL]-8-[4-(2-METHOXYETHYL)PIPERAZIN-1-YL]-3,3-DIMETHYL-1,4-DIHYDROPYRANO[3,4-C]PYRIDINE-5-CARBONITRILE'>5QF</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.5&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ng5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ng5 OCA], [http://pdbe.org/5ng5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ng5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ng5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ng5 ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5QF:6-[2-(3,4-DIMETHOXYPHENYL)ETHYLSULFANYL]-8-[4-(2-METHOXYETHYL)PIPERAZIN-1-YL]-3,3-DIMETHYL-1,4-DIHYDROPYRANO[3,4-C]PYRIDINE-5-CARBONITRILE'>5QF</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ng5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ng5 OCA], [https://pdbe.org/5ng5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ng5 RCSB], [https://www.ebi.ac.uk/pdbsum/5ng5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ng5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/ACRZ_ECOLI ACRZ_ECOLI]] AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.<ref>PMID:23010927</ref> [[http://www.uniprot.org/uniprot/ACRA_ECOLI ACRA_ECOLI]] AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm.<ref>PMID:9878415</ref> [[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref> [[http://www.uniprot.org/uniprot/TOLC_ECOLI TOLC_ECOLI]] Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.<ref>PMID:6337123</ref> <ref>PMID:11274125</ref> <ref>PMID:15228545</ref> <ref>PMID:18955484</ref> <ref>PMID:23176499</ref>
+
[https://www.uniprot.org/uniprot/ACRA_ECOLI ACRA_ECOLI] AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm.<ref>PMID:9878415</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 23:
__TOC__
__TOC__
</SX>
</SX>
 +
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Blaza, J N]]
+
[[Category: Blaza JN]]
-
[[Category: Chiu, W]]
+
[[Category: Chiu W]]
-
[[Category: Du, D]]
+
[[Category: Du D]]
-
[[Category: Fan, G]]
+
[[Category: Fan G]]
-
[[Category: Hryc, C F]]
+
[[Category: Hryc CF]]
-
[[Category: Luisi, B F]]
+
[[Category: Luisi BF]]
-
[[Category: Schmid, M F]]
+
[[Category: Schmid MF]]
-
[[Category: Serysheva, I I]]
+
[[Category: Serysheva II]]
-
[[Category: Wang, Z]]
+
[[Category: Wang Z]]
-
[[Category: Drug resistance]]
+
-
[[Category: Membrane protein]]
+
-
[[Category: Membrane transport]]
+
-
[[Category: Multi-drug efflux]]
+
-
[[Category: Rnd superfamily]]
+

Current revision

multi-drug efflux; membrane transport; RND superfamily; Drug resistance

5ng5, resolution 6.50Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5ng5"
Personal tools