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5tji

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Current revision (15:41, 6 March 2024) (edit) (undo)
 
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<SX load='5tji' size='340' side='right' viewer='molstar' caption='[[5tji]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
<SX load='5tji' size='340' side='right' viewer='molstar' caption='[[5tji]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5tji]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TJI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TJI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5tji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TJI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tj6|5tj6]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tji OCA], [http://pdbe.org/5tji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tji RCSB], [http://www.ebi.ac.uk/pdbsum/5tji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tji ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tji OCA], [https://pdbe.org/5tji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tji RCSB], [https://www.ebi.ac.uk/pdbsum/5tji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tji ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q5QJC5_APLCA Q5QJC5_APLCA]
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The precise control of an ion channel gate by environmental stimuli is crucial for the fulfilment of its biological role. The gate in Slo1 K+ channels is regulated by two separate stimuli, intracellular Ca2+ concentration and membrane voltage. Slo1 is thus central to understanding the relationship between intracellular Ca2+ and membrane excitability. Here we present the Slo1 structure from Aplysia californica in the absence of Ca2+ and compare it with the Ca2+-bound channel. We show that Ca2+ binding at two unique binding sites per subunit stabilizes an expanded conformation of the Ca2+ sensor gating ring. These conformational changes are propagated from the gating ring to the pore through covalent linkers and through protein interfaces formed between the gating ring and the voltage sensors. The gating ring and the voltage sensors are directly connected through these interfaces, which allow membrane voltage to regulate gating of the pore by influencing the Ca2+ sensors.
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Structural basis for gating the high-conductance Ca2+-activated K+ channel.,Hite RK, Tao X, MacKinnon R Nature. 2017 Jan 5;541(7635):52-57. doi: 10.1038/nature20775. Epub 2016 Dec 14. PMID:27974801<ref>PMID:27974801</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5tji" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</SX>
</SX>
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[[Category: Aplca]]
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[[Category: Aplysia californica]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hite, R K]]
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[[Category: Hite RK]]
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[[Category: MacKinnon, R]]
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[[Category: MacKinnon R]]
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[[Category: Tao, X]]
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[[Category: Tao X]]
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[[Category: Ca2+ bound]]
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[[Category: High conductance]]
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[[Category: Ion channel]]
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[[Category: K+ channel]]
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[[Category: Membrane protein]]
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Current revision

Ca2+ bound aplysia Slo1

5tji, resolution 3.80Å

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