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6bpq

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Current revision (14:23, 13 March 2024) (edit) (undo)
 
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<SX load='6bpq' size='340' side='right' viewer='molstar' caption='[[6bpq]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
<SX load='6bpq' size='340' side='right' viewer='molstar' caption='[[6bpq]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6bpq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Collared_flycatcher Collared flycatcher]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BPQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6BPQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6bpq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ficedula_albicollis Ficedula albicollis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BPQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BPQ FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRPM8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=59894 Collared flycatcher])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bpq OCA], [https://pdbe.org/6bpq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bpq RCSB], [https://www.ebi.ac.uk/pdbsum/6bpq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bpq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6bpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bpq OCA], [http://pdbe.org/6bpq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bpq RCSB], [http://www.ebi.ac.uk/pdbsum/6bpq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bpq ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/U3JD03_FICAL U3JD03_FICAL]
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Transient receptor potential melastatin (TRPM) cation channels are polymodal sensors that are involved in a variety of physiological processes. Within the TRPM family, member 8 (TRPM8) is the primary cold- and menthol-sensor in humans. We determined the cryo-electron microscopy structure of the full-length TRPM8 from the collared flycatcher at an overall resolution of ~4.1 A. Our TRPM8 structure reveals a three-layered architecture. The amino-terminal domain with a fold distinct among known TRP structures, together with the carboxyl-terminal region, forms a large two-layered cytosolic ring that extensively interacts with the transmembrane channel layer. The structure suggests that the menthol binding site is located within the voltage-sensor-like domain and thus provides a structural glimpse of the design principle of the molecular transducer for cold and menthol sensation.
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Structure of the cold- and menthol-sensing ion channel TRPM8.,Yin Y, Wu M, Zubcevic L, Borschel WF, Lander GC, Lee SY Science. 2017 Dec 7. pii: science.aan4325. doi: 10.1126/science.aan4325. PMID:29217583<ref>PMID:29217583</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6bpq" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Collared flycatcher]]
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[[Category: Ficedula albicollis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Borschel, W F]]
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[[Category: Borschel WF]]
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[[Category: Lander, G C]]
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[[Category: Lander GC]]
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[[Category: Lee, S Y]]
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[[Category: Lee S-Y]]
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[[Category: Wu, M]]
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[[Category: Wu M]]
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[[Category: Yin, Y]]
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[[Category: Yin Y]]
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[[Category: Zubcevic, L]]
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[[Category: Zubcevic L]]
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[[Category: Calcium-permeable ion channel]]
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[[Category: Cold sensor]]
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[[Category: Ion channel]]
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[[Category: Menthol sensor]]
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[[Category: Transport protein]]
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Current revision

Structure of the cold- and menthol-sensing ion channel TRPM8

6bpq, resolution 4.10Å

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