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6mat

From Proteopedia

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<SX load='6mat' size='340' side='right' viewer='molstar' caption='[[6mat]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
<SX load='6mat' size='340' side='right' viewer='molstar' caption='[[6mat]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6mat]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MAT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MAT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6mat]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MAT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTHT_0002840 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mat OCA], [https://pdbe.org/6mat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mat RCSB], [https://www.ebi.ac.uk/pdbsum/6mat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mat ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mat OCA], [http://pdbe.org/6mat PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mat RCSB], [http://www.ebi.ac.uk/pdbsum/6mat PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mat ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/G0RZG1_CHATD G0RZG1_CHATD]
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Rix7 is an essential type II AAA-ATPase required for the formation of the large ribosomal subunit. Rix7 has been proposed to utilize the power of ATP hydrolysis to drive the removal of assembly factors from pre-60S particles, but the mechanism of release is unknown. Rix7's mammalian homolog, NVL2 has been linked to cancer and mental illness disorders, highlighting the need to understand the molecular mechanisms of this essential machine. Here we report the cryo-EM reconstruction of the tandem AAA domains of Rix7 which form an asymmetric stacked homohexameric ring. We trapped Rix7 with a polypeptide in the central channel, revealing Rix7's role as a molecular unfoldase. The structure establishes that type II AAA-ATPases lacking the aromatic-hydrophobic motif within the first AAA domain can engage a substrate throughout the entire central channel. The structure also reveals that Rix7 contains unique post-alpha7 insertions within both AAA domains important for Rix7 function.
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Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7.,Lo YH, Sobhany M, Hsu AL, Ford BL, Krahn JM, Borgnia MJ, Stanley RE Nat Commun. 2019 Jan 31;10(1):513. doi: 10.1038/s41467-019-08373-0. PMID:30705282<ref>PMID:30705282</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6mat" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Chatd]]
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[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Borgnia, M J]]
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[[Category: Borgnia MJ]]
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[[Category: Ford, B L]]
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[[Category: Ford BL]]
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[[Category: Hsu, A L]]
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[[Category: Hsu AL]]
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[[Category: Krahn, J M]]
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[[Category: Krahn JM]]
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[[Category: Lo, Y H]]
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[[Category: Lo YH]]
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[[Category: Sobhany, M]]
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[[Category: Sobhany M]]
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[[Category: Stanley, R E]]
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[[Category: Stanley RE]]
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[[Category: Aaa-atpase]]
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[[Category: Ribosomal protein]]
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Current revision

Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7

6mat, resolution 4.50Å

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