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6r9g

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Current revision (10:09, 22 May 2024) (edit) (undo)
 
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<SX load='6r9g' size='340' side='right' viewer='molstar' caption='[[6r9g]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<SX load='6r9g' size='340' side='right' viewer='molstar' caption='[[6r9g]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6r9g]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6R9G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6r9g]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Escherichia_phage_T7 Escherichia phage T7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R9G FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6r9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9g OCA], [http://pdbe.org/6r9g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r9g RCSB], [http://www.ebi.ac.uk/pdbsum/6r9g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9g ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9g OCA], [https://pdbe.org/6r9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r9g RCSB], [https://www.ebi.ac.uk/pdbsum/6r9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RPOZ_ECOLI RPOZ_ECOLI]] Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.[HAMAP-Rule:MF_00366] [[http://www.uniprot.org/uniprot/RPOA_ECOLI RPOA_ECOLI]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.[HAMAP-Rule:MF_00059] [[http://www.uniprot.org/uniprot/RPOC_ECOLI RPOC_ECOLI]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01322] [[http://www.uniprot.org/uniprot/RPOB_ECOLI RPOB_ECOLI]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01321]
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[https://www.uniprot.org/uniprot/RPOA_ECOLI RPOA_ECOLI] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.[HAMAP-Rule:MF_00059]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6r9g" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6r9g" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</SX>
</SX>
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Escherichia coli K-12]]
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[[Category: Escherichia phage T7]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ye, F Z]]
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[[Category: Ye FZ]]
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[[Category: Zhang, X D]]
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[[Category: Zhang XD]]
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[[Category: Bacteriophage]]
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[[Category: Ocr]]
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[[Category: Rna polymerase]]
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[[Category: Transcription]]
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[[Category: Transcription inhibition]]
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Current revision

Structural basis of transcription inhibition by the DNA mimic Ocr protein of bacteriophage T7

6r9g, resolution 3.70Å

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OCA

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