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Tailspike protein

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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='3th0' size='340' side='right' caption='Glycosylated tailspike protein from bacteriophage P222 complex with octasaccharide (PDB code [[3th0]])' scene='84/841073/Cv/1'>
== Function ==
== Function ==
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'''Tailspike protein''' (TSP) of bacteriophage P22 is a trimeric protein which serves as the receptor-binding protein of the bacteriophage to its bacterial host<ref>PMID:29500571</ref>.
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The '''tailspike protein''' (TSP) of bacteriophage is a trimeric protein which serves as the receptor-binding protein of the bacteriophage to its bacterial host<ref>PMID:29500571</ref>. O-antigen polysaccharides found on the outer surface of bacteria are the natural substrates for TSP<ref>PMID:20817910</ref>.
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== Disease ==
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== Relevance ==
== Relevance ==
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Bacteriophage research is becoming important due to the problem of antibiotics resistance. TSP binding to pathogenic bacteria can be used for their detection<ref>PMID:30111705</ref>.
== Structural highlights ==
== Structural highlights ==
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The N-terminal domain (NTD) (residues 1-108) of TSP is responsible for the attachment
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The C-terminal domain (CTD) (residues 109-end) of TSP is responsible for the attachment of the tailspike protein to the O-antigen moiety on bacterial cell surface. The 3D structure of an <scene name='84/841073/Cv/3'>octasaccharide</scene> bound to CTP of TSP shows <scene name='84/841073/Cv/7'>numerous hydrophobic interactions as well as defined water molecules forming hydrogen bonds to the antigen</scene><ref>PMID:23292517</ref>.
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</StructureSection>
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==3D structures of tailspike protein==
==3D structures of tailspike protein==
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[[Tailspike protein 3D structures]]
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[[2xc1]] - P22TSP - bacteriophage P22<br />
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[[1lkt]] - P22TSP NTD<br />
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[[2vky]] - P22TSP NTD/isoleucine zipper<br />
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[[2vnl]] - P22TSP NTD/isoleucine zipper (mutant)<br />
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[[1tyv]], [[1tyu]], [[1tyx]], [[1tyw]], [[2vfm]], [[1tsp]] - P22TSP CTD <br />
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[[1qq1]], [[1qrc]], [[1qrb]], [[2vfp]], [[2vfo]], [[2vfq]], [[1qa3]], [[1qa2]], [[1qa1]], [[2vfn]], [[1clw]] - P22TSP CTD 109-667 (mutant)<br />
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[[3th0]] - P22TSP CTD + octasaccharide<br />
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[[2vji]] - HK620TSP NTD - bacteriophage HK620<br />
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[[4avz]], [[4xon]], [[4xqf]], [[4xlc]], [[4xl9]], [[4xkv]], [[4xlh]], [[4xnf]], [[4xn0]] - HK520TSP CTD (mutant)<br />
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[[2x85]], [[2vjj]], [[2x6x]] - HK520TSP CTD + hexasaccharide<br />
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[[2x6w]], [[2x6y]], [[4xla]], [[5xop]], [[5xor]], [[4xr6]], [[4yej]], [[4yel]], [[4xle]], [[4xlf]], [[4xkw]], [[4xm3]], [[4xmy]], [[4xn3]], [[4xot]] - HK520TSP CTD (mutant) + polysaccharide<br />
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[[2vbe]] - TSP CTD - bacteriophage SFVI<br />
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[[2vbk]] - SF6TSP CTD - bacteriophage SF6<br />
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[[2vbm]] - SF6TSP CTD + tetrasaccharide<br />
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[[6nw9]], [[5w6f]] - CBA120TSP3 - bacteriophage CBA120<br />
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[[5w6h]] - CBA120TSP4 active domain 344-1056<br />
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[[6f7d]] - SF6TSP CTD - bacteriophage DET7<br />
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[[5js4]] - TSP - bacteriophage PHIAB6<br />
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
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[[Category:Topic Page]]

Current revision

Glycosylated tailspike protein from bacteriophage P222 complex with octasaccharide (PDB code 3th0)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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