6wfs
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6wfs is ON HOLD Authors: Schlicksup, C., Laughlin, P., Dunkelbarger, S., Wang, J.C., Zlotnick, A. Description: Cryo-EM Structure of Hepatitis B vir...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM Structure of Hepatitis B virus T=4 capsid in complex with the antiviral molecule DBT1== | |
| - | + | <StructureSection load='6wfs' size='340' side='right'caption='[[6wfs]], [[Resolution|resolution]] 4.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6wfs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus_subtype_adyw Hepatitis B virus subtype adyw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WFS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.6Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U0A:11-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide'>U0A</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wfs OCA], [https://pdbe.org/6wfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wfs RCSB], [https://www.ebi.ac.uk/pdbsum/6wfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wfs ProSAT]</span></td></tr> |
| - | [[Category: Laughlin | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Wang | + | [https://www.uniprot.org/uniprot/CAPSD_HBVD1 CAPSD_HBVD1] Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with a icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions (By similarity).<ref>PMID:7711014</ref> Encapsidates hepatitis delta genome (By similarity).<ref>PMID:7711014</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hepatitis B virus subtype adyw]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dunkelbarger S]] | ||
| + | [[Category: Laughlin P]] | ||
| + | [[Category: Schlicksup C]] | ||
| + | [[Category: Wang JC]] | ||
| + | [[Category: Zlotnick A]] | ||
Current revision
Cryo-EM Structure of Hepatitis B virus T=4 capsid in complex with the antiviral molecule DBT1
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