6wgi

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m (Protected "6wgi" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6wgi is ON HOLD until sometime in the future
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==Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at 10.5 A resolution==
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<StructureSection load='6wgi' size='340' side='right'caption='[[6wgi]], [[Resolution|resolution]] 10.00&Aring;' scene=''>
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Authors: Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6wgi]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WGI FirstGlance]. <br>
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Description: Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Bai, L]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wgi OCA], [https://pdbe.org/6wgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wgi RCSB], [https://www.ebi.ac.uk/pdbsum/6wgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wgi ProSAT]</span></td></tr>
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[[Category: Riera, A]]
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</table>
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[[Category: Li, H]]
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== Function ==
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[[Category: Ivanov, I]]
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[https://www.uniprot.org/uniprot/CDC6_YEAST CDC6_YEAST] Plays a crucial role in forming the pre-replicative complexes. Interacts with the origin recognition complex (ORC) and MCM2-7 helicase complex leading to the linking of those complexes and loading of the replicative helicase MCM2-7 onto the pre-replicative complexes. Required for the initiation of DNA replication and then actively participates in the suppression of nuclear division.<ref>PMID:10075735</ref> <ref>PMID:1600944</ref> <ref>PMID:23603117</ref> <ref>PMID:7641697</ref> <ref>PMID:8538771</ref> <ref>PMID:8978693</ref> <ref>PMID:9099949</ref> <ref>PMID:9312054</ref> <ref>PMID:9892652</ref>
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[[Category: Yuan, Z]]
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== References ==
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[[Category: Dodd, T]]
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<references/>
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[[Category: Yan, C]]
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__TOC__
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[[Category: Stillman, B]]
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</StructureSection>
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[[Category: Speck, C]]
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[[Category: Large Structures]]
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[[Category: Schneider, S]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Magdalou, I]]
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[[Category: Bai L]]
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[[Category: Dodd T]]
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[[Category: Ivanov I]]
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[[Category: Li H]]
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[[Category: Magdalou I]]
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[[Category: Riera A]]
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[[Category: Schneider S]]
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[[Category: Speck C]]
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[[Category: Stillman B]]
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[[Category: Yan C]]
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[[Category: Yuan Z]]

Current revision

Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at 10.5 A resolution

PDB ID 6wgi

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OCA

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