6lt0

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==cryo-EM structure of C9ORF72-SMCR8-WDR41==
==cryo-EM structure of C9ORF72-SMCR8-WDR41==
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<StructureSection load='6lt0' size='340' side='right'caption='[[6lt0]]' scene=''>
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<StructureSection load='6lt0' size='340' side='right'caption='[[6lt0]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LT0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LT0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6lt0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LT0 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lt0 OCA], [http://pdbe.org/6lt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lt0 RCSB], [http://www.ebi.ac.uk/pdbsum/6lt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lt0 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lt0 OCA], [https://pdbe.org/6lt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lt0 RCSB], [https://www.ebi.ac.uk/pdbsum/6lt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lt0 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WDR41_HUMAN WDR41_HUMAN] Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).<ref>PMID:27103069</ref> <ref>PMID:27193190</ref> <ref>PMID:27617292</ref> <ref>PMID:28195531</ref>
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Qi S]]
[[Category: Qi S]]

Current revision

cryo-EM structure of C9ORF72-SMCR8-WDR41

PDB ID 6lt0

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