6wcc

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==Human closed state TMEM175 in CsCl==
==Human closed state TMEM175 in CsCl==
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<StructureSection load='6wcc' size='340' side='right'caption='[[6wcc]]' scene=''>
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<StructureSection load='6wcc' size='340' side='right'caption='[[6wcc]], [[Resolution|resolution]] 3.24&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WCC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WCC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6wcc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WCC FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wcc OCA], [http://pdbe.org/6wcc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wcc RCSB], [http://www.ebi.ac.uk/pdbsum/6wcc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wcc ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.24&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wcc OCA], [https://pdbe.org/6wcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wcc RCSB], [https://www.ebi.ac.uk/pdbsum/6wcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wcc ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry. TMEM175 defects result in unstable lysosomal pH, leading to decreased lysosomal catalytic activity, decreased glucocerebrosidase activity, impaired autophagosome clearance by the lysosome and decreased mitochondrial respiration (PubMed:28193887).<ref>PMID:28193887</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.<ref>PMID:26317472</ref> <ref>PMID:28723891</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hite RK]]
[[Category: Hite RK]]
[[Category: Oh S]]
[[Category: Oh S]]
[[Category: Paknejad N]]
[[Category: Paknejad N]]

Current revision

Human closed state TMEM175 in CsCl

PDB ID 6wcc

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