This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6jky

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:14, 22 November 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='6jky' size='340' side='right'caption='[[6jky]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='6jky' size='340' side='right'caption='[[6jky]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6jky]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human], [http://en.wikipedia.org/wiki/Legph Legph] and [http://en.wikipedia.org/wiki/Schistosoma_margrebowiei Schistosoma margrebowiei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JKY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JKY FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6jky]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1] and [https://en.wikipedia.org/wiki/Schistosoma_margrebowiei Schistosoma margrebowiei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JKY FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpg2148 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), UBE2N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SMRZ_LOCUS12712 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=48269 Schistosoma margrebowiei])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.454&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/E2_ubiquitin-conjugating_enzyme E2 ubiquitin-conjugating enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.23 2.3.2.23] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jky OCA], [https://pdbe.org/6jky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jky RCSB], [https://www.ebi.ac.uk/pdbsum/6jky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jky ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jky OCA], [http://pdbe.org/6jky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jky RCSB], [http://www.ebi.ac.uk/pdbsum/6jky PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jky ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/UBE2N_HUMAN UBE2N_HUMAN]] The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity).<ref>PMID:10089880</ref> <ref>PMID:14562038</ref> <ref>PMID:19269966</ref> <ref>PMID:20061386</ref> <ref>PMID:21512573</ref>
+
[https://www.uniprot.org/uniprot/Q5ZTL3_LEGPH Q5ZTL3_LEGPH]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 18:
</div>
</div>
<div class="pdbe-citations 6jky" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6jky" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[3D structures of ubiquitin|3D structures of ubiquitin]]
 +
*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: E2 ubiquitin-conjugating enzyme]]
+
[[Category: Homo sapiens]]
-
[[Category: Human]]
+
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Legph]]
+
[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]]
[[Category: Schistosoma margrebowiei]]
[[Category: Schistosoma margrebowiei]]
-
[[Category: Guan, H]]
+
[[Category: Guan H]]
-
[[Category: Ouyang, S Y]]
+
[[Category: Ouyang SY]]
-
[[Category: Legionella pneumophila effect factor complex]]
+
-
[[Category: Signaling protein]]
+

Current revision

Crystal structure of MvcA-UBE2N-Ub complex from Legionella pneumophila

PDB ID 6jky

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6jky"
Personal tools