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2jeo

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<StructureSection load='2jeo' size='340' side='right'caption='[[2jeo]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2jeo' size='340' side='right'caption='[[2jeo]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jeo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JEO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jeo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JEO FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_kinase Uridine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.48 2.7.1.48] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeo OCA], [http://pdbe.org/2jeo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jeo RCSB], [http://www.ebi.ac.uk/pdbsum/2jeo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jeo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeo OCA], [https://pdbe.org/2jeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jeo RCSB], [https://www.ebi.ac.uk/pdbsum/2jeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jeo ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UCK1_HUMAN UCK1_HUMAN] Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702).<ref>PMID:11306702</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jeo ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jeo ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Uridine kinase]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C]]
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[[Category: Berglund H]]
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[[Category: Berg, S van den]]
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[[Category: Busam R]]
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[[Category: Berglund, H]]
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[[Category: Collins R]]
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[[Category: Busam, R]]
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[[Category: Edwards A]]
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[[Category: Collins, R]]
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[[Category: Ericsson UB]]
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[[Category: Edwards, A]]
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[[Category: Flodin S]]
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[[Category: Ericsson, U B]]
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[[Category: Flores A]]
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[[Category: Flodin, S]]
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[[Category: Graslund S]]
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[[Category: Flores, A]]
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[[Category: Hallberg BM]]
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[[Category: Graslund, S]]
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[[Category: Hammarstrom M]]
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[[Category: Hallberg, B M]]
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[[Category: Hogbom M]]
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[[Category: Hammarstrom, M]]
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[[Category: Holmberg Schiavone L]]
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[[Category: Hogbom, M]]
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[[Category: Johansson I]]
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[[Category: Johansson, I]]
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[[Category: Karlberg T]]
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[[Category: Karlberg, T]]
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[[Category: Kosinska U]]
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[[Category: Kosinska, U]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T]]
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[[Category: Moche M]]
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[[Category: Moche, M]]
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[[Category: Nilsson MEP]]
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[[Category: Nilsson, M E.P]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P]]
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[[Category: Nyman T]]
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[[Category: Nyman, T]]
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[[Category: Ogg D]]
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[[Category: Ogg, D]]
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[[Category: Persson C]]
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[[Category: Persson, C]]
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[[Category: Sagemark J]]
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[[Category: Structural genomic]]
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[[Category: Stenmark P]]
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[[Category: Sagemark, J]]
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[[Category: Sundstrom M]]
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[[Category: Schiavone, L Holmberg]]
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[[Category: Thorsell AG]]
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[[Category: Stenmark, P]]
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[[Category: Uppenberg J]]
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[[Category: Sundstrom, M]]
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[[Category: Uppsten M]]
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[[Category: Thorsell, A G]]
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[[Category: Weigelt J]]
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[[Category: Uppenberg, J]]
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[[Category: Welin M]]
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[[Category: Uppsten, M]]
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[[Category: Van den Berg S]]
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[[Category: Weigelt, J]]
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[[Category: Welin, M]]
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[[Category: Atp-binding]]
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[[Category: Kinase]]
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[[Category: Nucleoside kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Transferase]]
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[[Category: Uck]]
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Current revision

Crystal structure of human uridine-cytidine kinase 1

PDB ID 2jeo

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