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Virus protease 3D structures

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== 3D Structures of Virus proteases ==
+
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} - For a general description of the protein see [[Virus protease]]
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+
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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**[[2b7f]] – HTLV-PV + peptide<br />
**[[2b7f]] – HTLV-PV + peptide<br />
-
**[[3lin]], [[3liq]], [[3lit]], [[3liv]], [[3lix]], [[3liy]], [[4ydg]], [[4ydf]] – HTLV-PV (mutant) + inhibitor<br />
+
**[[3lin]], [[3liq]], [[3lit]], [[3liv]], [[3lix]], [[3liy]], [[3wsj]], [[4ydg]], [[4ydf]] – HTLV-PV (mutant) + inhibitor<br />
*'''Rous sarcoma virus protease'''
*'''Rous sarcoma virus protease'''
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**[[1bai]] – RSVP + polypeptide inhibitor
**[[1bai]] – RSVP + polypeptide inhibitor
-
*'''Human Cytomegalovirus protease'''
+
*'''Human Cytomegalovirus or (human betaherpesvirus 5) protease'''
-
**[[1wpo]] – CMVP - human herpes virus 5<br />
+
**[[1wpo]] – CMVP <br />
**[[1cmv]], [[1lay]], [[1jq6]], [[1id4]], [[1iec]], [[1ied]], [[1ief]], [[1ieg]] – CMVP (mutant) <br />
**[[1cmv]], [[1lay]], [[1jq6]], [[1id4]], [[1iec]], [[1ied]], [[1ief]], [[1ieg]] – CMVP (mutant) <br />
**[[2wpo]], [[1jq7]] - CMVP (mutant) + inhibitor<br />
**[[2wpo]], [[1jq7]] - CMVP (mutant) + inhibitor<br />
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*'''Varicella-Zoster virus protease'''
*'''Varicella-Zoster virus protease'''
-
**[[1vzv]] - VZVP (mutant) – human herpes virus
+
**[[1vzv]] - VZVP (mutant) – human alphaherpesvirus 3
*'''Equine infectious anemia virus protease'''
*'''Equine infectious anemia virus protease'''
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*'''Hepatitis C virus protease'''
*'''Hepatitis C virus protease'''
-
**[[2o8m]] – HCVP (mutant)<br />
+
**[[1a1r]], [[1jxp]], [[1ns3]], [[3kf2]], [[3rc6]], [[4b6e]], [[4b6f]] – HCVP NS3/A4<br />
-
**[[2a4g]], [[2gvf]], [[2f9u]], [[2f9v]] – HCVP + peptide inhibitor<br />
+
**[[2o8m]], [[2oin]], [[4b71]], [[4b73]], [[4b74]], [[4b75]], [[4b76]], [[6vdn]], [[6vdo]] – HCVP (mutant)<br />
-
**[[6nzt]], [[6nzv]], [[6piu]], [[6piv]], [[6piw]], [[6pix]], [[6piy]], [[6piz]], [[6pj0]], [[6pj1]], [[6pj2]] – HCVP (mutant) + inhibitor<br />
+
**[[1bt7]] – HCVP NS3 N terminal - NMR<br />
 +
**[[1w3c]], [[2a4g]], [[2gvf]], [[2f9u]], [[2f9v]], [[3m5m]], [[3m5n]], [[3m5o]], [[3oyp]], [[4a1t]], [[4a1v]], [[4a1x]], [[4jmy]] – HCVP + peptide inhibitor<br />
 +
**[[1dxp]], [[1dy8]], [[1dy9]], [[1rtl]], [[2a4g]], [[2a4q]], [[2f9u]], [[2f9v]], [[2fm2]], [[2gvf]], [[2obo]], [[2oc1]], [[2oc7]], [[2oc8]], [[2xcf]], [[2xcn]], [[2xni]], [[3eyd]], [[3kee]], [[3kn2]], [[3knx]], [[3m5l]], [[3lon]], [[3p8n]], [[3p8o]], [[3sud]], [[4a92]], [[4i31]], [[4k8b]], [[4ktc]], [[4nwl]], [[4tyd]], [[4u01]], [[4wxp]], [[5eqq]], [[5fpy]], [[5voj]], [[5vp9]], [[6cvw]], [[6cvx]], [[6cvy]], [[6diq]], [[6dir]], [[6dis]], [[6dit]], [[6diu]], [[6nzv]], [[7d5l]] – HCVP NS3/A4 + inhibitor<br />
 +
**[[6pj2]] – HCVP NS3/A4 (mutant) + inhibitor - NMR<br />
 +
**[[3sue]], [[3suf]], [[3sug]], [[4i32]], [[4i33]], [[5epn]], [[5epy]], [[5etx]], [[6c2m]], [[6div]], [[6diw]], [[6nzt]], [[6nzv]], [[6piu]], [[6piv]], [[6piw]], [[6pix]], [[6piy]], [[6piz]], [[6pj0]] – HCVP NS3/A4 (mutant) + inhibitor<br />
 +
**[[1a1q]], [[5wdx]] – HCVP NS3<br />
 +
**[[2oc0]], [[3r7b]], [[4nwk]], [[4ojq]], [[4ok3]], [[4ok5]], [[4ok6]], [[4oks]], [[4wxr]], [[5fps]], [[5fpt]] – HCVP NS3 + inhibitor<br />
 +
**[[2k1q]], [[6fe6]] – HCVP NS3 + inhibitor - NMR<br />
 +
**[[5e4f]] – HCVP NS3 + ADP<br />
 +
**[[3kql]], [[3kqn]], [[3kqu]] – HCVP NS3 + RNA<br />
 +
**[[2f55]] – HCVP NS3 + DNA<br />
 +
**[[3lox]], [[3su3]], [[3sv6]], [[3sv9]], [[4wf8]], [4wh8]], [[5eqr]], [[5esb]], [[6nzt]], [[6p6l]], [[6p6m]], [[6p6q]], [[6p6r]], [[6p6s]], [[6p6t]], [[6p6v]], [[6p6z]] – HCVP NS3/A4 + drug<br />
 +
**[[3su0]], [[3su1]], [[3su2]], [[3su4]], [[3su5]], [[3su6]], [[3sv7]], [[3sv8]], [[4wh6]], [[5esq]], [[6c2n]], [[6p6o]], [[6vdl]], [[6vdm]] – HCVP NS3/A4 (mutant) + drug<br />
*'''Orf 17'''
*'''Orf 17'''
-
**[[3njq]] – hOrf 17 - human herpes virus 8
+
**[[3njq]] – hOrf 17 - human gammaherpesvirus 8<br />
 +
**[[3njq]], [[5ur3]], [[5ute]], [[5utn]], [[5uv3]], [[5uvp]], [[5v5d]], [[5v5e]] – hOrf 17 + inhibitor<br />
*'''Dengue virus protease'''
*'''Dengue virus protease'''
-
**[[3u1i]] – DvNs2b + peptide – Dengue virus<br />
+
**[[3lkw]] – Dv12Ns2b/Dv12Ns3 (mutant) - Dengue virus 1<br />
-
**[[3u1j]] – DvNs2b + BPTI<br />
+
**[[4m9f]], [[4m9i]], [[4m9k]], [[4m9m]] - Dv2Ns2b/Dv2Ns3 (mutant) - Dengue virus 2<br />
-
**[[2fom]] - DvNs2b/DvNs3<br />
+
**[[6mo0]], [[6mo1]], [[6mo2]] – Dv2Ns2b + inhibitor<br />
-
**[[4m9f]], [[4m9i]], [[4m9k]], [[4m9m]], [[3lkw]] - DvNs2b/DvNs3 (mutant)<br />
+
**[[4m9t]] - Dv2Ns2b/Dv2Ns3 (mutant) + inhibitor<br />
-
**[[6mo0]], [[6mo1]], [[6mo2]] - DvNs2b residues 1394-1440 + inhibitor<br />
+
**[[2m9p]], [[2m9q]] – Dv2Ns2b/Dv2Ns3 + inhibitor - NMR<br />
-
**[[4m9t]] - DvNs2b/DvNs3 (mutant) + inhibitor<br />
+
**[[3u1i]] – Dv3Ns2b + peptide – Dengue virus 3<br />
-
**[[2jlq]] – DvNs3 residues 1646-2092 <br />
+
**[[3u1j]] – Dv3Ns2b/Dv3Ns3 + inhibitor<br />
-
**[[2jlv]] – DvNs3 residues 1646-2092 + AMPPNP + RNA<br />
+
**[[2jlq]], [[5yvu]], [[5yvv]], [[5yvw]], [[5yvy]] – Dv4Ns3 – Dengue virus 4<br />
-
**[[2jlr]] – DvNs3 residues 1646-2092 + AMPPNP<br />
+
**[[5xc7]] – Dv4Ns3 (mutant)<br />
-
**[[2jls]] – DvNs3 residues 1646-2092 + ADP<br />
+
**[[5yvj]] – Dv4Ns2b/Dv4Ns3 <br />
-
**[[2jlx]], [[2jly]], [[2jlz]] – DvNs3 residues 1646-2092 + ADP + RNA<br />
+
**[[2whx]] – Dv4Ns2b/Dv4Ns3 + ADP<br />
-
**[[2jlu]], [[2jlw]] – DvNs3 residues 1646-2092 + RNA<br />
+
**[[2jlr]] – Dv4Ns3 + AMPPNP <br />
-
**[[2vbc]], [[2whx]], [[2wzq]] – DvNs3 residues 1475-2092 + peptide inhibitor<br />
+
**[[2jlu]], [[2jlw]] – Dv4Ns3 + RNA<br />
-
**[[2m9p]], [[2m9q]] – DvNs3 residues 1475-1648 + peptide inhibitor - NMR<br />
+
**[[2jls]], [[2jlx]], [[2jly]], [[2jlz]] – Dv4Ns3 + ADP + RNA<br />
-
**[[6izy]] – DvNs5 RNA polymerase domain residues 2742-3387 <br />
+
**[[2jlv]] – Dv4Ns3 + AMPPNP + RNA<br />
-
**[[6izx]] – DvNs5 RNA polymerase domain residues 2742-3387 + inhibitor<br />
+
**[[5yw1]] – Dv4Ns3 + BPTI <br />
 +
**[[2vbc]], [[2wzq]] – Dv4Ns3 residues 1475-2092 + peptide inhibitor<br />
*'''Herpes simplex virus protease'''
*'''Herpes simplex virus protease'''
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**[[2jqf]], [[2j92]], [[5hm2]] – FMDV (mutant) <br />
**[[2jqf]], [[2j92]], [[5hm2]] – FMDV (mutant) <br />
**[[2wv4]], [[2wv5]] – FMDV (mutant) + peptide <br />
**[[2wv4]], [[2wv5]] – FMDV (mutant) + peptide <br />
 +
**[[1qmy]], [[1qol]] – FMDV residues 29-201 (mutant) <br />
 +
**[[4qbb]] – FMDV residues 29-201 + inhibitor <br />
*'''Infectious Bronchitis virus protease'''
*'''Infectious Bronchitis virus protease'''
-
**[[2q6d]], [[4x2z]] – IBV – infectious bronchitis virus <br />
+
**[[2q6d]], [[4x2z]] – IBV Ns3 – infectious bronchitis virus <br />
**[[2q6f]] – IBV + inhibitor
**[[2q6f]] – IBV + inhibitor
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**[[6urv]] – NS2B + NS3 <br />
**[[6urv]] – NS2B + NS3 <br />
 +
**[[5ffm]] – NS3 <br />
*'''Zika virus protease'''
*'''Zika virus protease'''
-
**[[6um3]], [[6jpw]] – NS2B + NS3 <br />
+
**[[5gj4]], [[5gxj]], [[5t1v]], [[5tfn]], [[6um3]], [[6jpw]] – NS2B + NS3 <br />
 +
**[[5tfo]], [[6um3]] – NS2B + NS3 (mutant)<br />
 +
**[[5jmt]], [[5jps]], [[5jrz]], [[5jwh]], [[5txg]], [[5vi7]], [[6adw]], [[6mh3]] – NS3 <br />
 +
**[[5k8i]], [[5k8l]], [[5k8t]], [[5k8u]], [[5y4z]], [[5y6m]], [[6adx]], [[6ady]], [[6rwz]], [[6s0j]] – NS3 + nucleotide <br />
 +
**[[5gjb]], [[5mfx]] – NS3 + RNA <br />
 +
**[[5rhg]], [[5rhh]], [[5rhi]], [[5rhj]], [[5rhk]], [[5rhl]], [[5rhm]], [[5rho]], [[5rhp]], [[5rhq]], [[5rhr]], [[5rhs]], [[5rht]], [[5rhu]], [[5rhv]], [[5rhw]], [[5rhx]], [[5rhy]]– NS3 + inhibitor<br />
 +
**[[5gjc]], [[5gpi]], [[5h4i]], [[5h6v]], [[5lc0]], [[5yod]], [[5yof]], [[5zmq]], [[5zms]], [[5zob]], [[6jpw]], [[6kk2]], [[6kk3]], [[6kk4]], [[6kk5]], [[6kk6]], [[6kpq]], [[6l4z]], [[6l50]], [[6y3b]] – NS2B + NS3 + inhibitor<br />
*'''Pseudorabies virus protease'''
*'''Pseudorabies virus protease'''
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*'''Coxsakievirus protease'''
*'''Coxsakievirus protease'''
-
**[[2vb0]], [[2zty]], [[2ztz]], [[3zyd]], [[3sj8]] – CSVP <br />
+
**[[4mg3]] – CSVP A2 863-1007 - Coxsakievirus A16 <br />
-
**[[2zu1]], [[3zye]], [[3zz3]], [[3zz4]] – CSVP (mutant) <br />
+
**[[3sj8]] – CSVP 3C 1-183 <br />
-
**[[2ztx]] – CSVP + Zn-H2S <br />
+
**[[2vb0]], [[2zty]], [[2ztz]], [[3zyd]] – CSVP 3C 14-196 - Coxsakievirus B3 <br />
-
**[[2zu3]], [[3zz5]], [[3zz6]], [[3zz7]], [[3zz8]], [[3zz9]], [[3zza]], [[3zzb]], [[3sji]] – CSVP + inhibitor <br />
+
**[[2zu1]], [[3zye]], [[3zz3]], [[3zz4]] – CSVP 3C (mutant) <br />
-
**[[3zzc]], [[3zzd]] – CSVP (mutant) + inhibitor <br />
+
**[[2ztx]] – CSVP 3C + Zn-H2S <br />
-
**[[3sj9]] – CSVP (mutant) + peptide inhibitor <br />
+
**[[2zu3]], [[3zz5]], [[3zz6]], [[3zz7]], [[3zz8]], [[3zz9]], [[3zza]], [[3zzb]], [[3sji]], [[5nfs]] – CSVP 3C + inhibitor <br />
 +
**[[3zzc]], [[3zzd]] – CSVP 3C (mutant) + inhibitor <br />
 +
**[[3sj9]] – CSVP 3C (mutant) + peptide inhibitor <br />
-
*'''Human polio virus protease'''
+
*'''Human poliovirus 3C protease'''
**[[1l1n]] – HPV <br />
**[[1l1n]] – HPV <br />
**[[2ijd]] – HPV (mutant) <br />
**[[2ijd]] – HPV (mutant) <br />
 +
**[[4dcd]] – HPV + peptide inhibitor <br />
*'''Human rhinovirus protease'''
*'''Human rhinovirus protease'''
-
**[[2in2]] – HRVP – human rhinovirus - NMR <br />
+
**[[2in2]], [[2m5t]] – HRVP – human rhinovirus A2 - NMR <br />
**[[1cqq]], [[2xya]], [[5fx5]], [[5fx6]], [[6ffn]], [[6ffs]] – HRVP + inhibitor <br />
**[[1cqq]], [[2xya]], [[5fx5]], [[5fx6]], [[6ffn]], [[6ffs]] – HRVP + inhibitor <br />
 +
**[[6kyz]], [[6kz0]] – HRVP + antibody – human rhinovirus B14 <br />
**[[2b0f]] – HRVP + inhibitor – NMR <br />
**[[2b0f]] – HRVP + inhibitor – NMR <br />
-
**[[2h6m]] – HRVP + peptide inhibitor <br />
+
**[[6ku7]] – HRVP – human rhinovirus C<br />
 +
**[[6ku8]] – HRVP + drug <br />
 +
**[[5x45]] – HRVP 2A – human rhinovirus C15 <br />
-
*'''Human enterovirus protease'''
+
*'''Human enterovirus protease A71'''
-
**[[3osy]] – HEVP 71 – human enterovirus <br />
+
**[[3osy]], [[4ghq]], [[8cny]] – HEVP <br />
-
**[[3zv8]] – HEVP 68 residues 1549-1731 <br />
+
**[[3r0f]] – HEVP (mutant) <br />
-
**[[3q3x]] – HEVP B (mutant) <br />
+
**[[3sjk]] – HEVP (mutant) + peptide inhibitor <br />
-
**[[3q3y]] – HEVP B (mutant) + inhibitor <br />
+
**[[4ght]], [[5bpe]], [[5c1u]], [[5c1x]], [[5c1y]], [[5c20]], [[5dp3]], [[5dp4]], [[5dp5]], [[5dp6]], [[5dp7]], [[5dp8]], [[5dp9]], [[5dpa]], [[5gso]], [[5gsw]], [[5hxf]], [[5wq2]], [[6lka]], [[7dnc]] – HEVP + inhibitor <br />
-
**[[3ruo]] – HEVP B + inhibitor <br />
+
**[[3sjo]], [[5hxf]], [[5wq2]] – HEVP + drug <br />
-
**[[3sjk]] – HEVP 71 (mutant) + peptide inhibitor <br />
+
**[[3qzq]], [[3qzr]], [[3r0f]] – HEVP (mutant) + drug <br />
-
**[[3sjo]], [[5bpe]], [[5hxf]], [[5wq2]] – HEVP 71 + inhibitor <br />
+
 
-
**[[3qzq]], [[3qzr]] – HEVP 71 (mutant) + inhibitor <br />
+
*'''Human enterovirus protease B'''
-
**[[3zv9]], [[3zva]], [[3zvb]], [[3zvc]], [[3zvd]], [[3zve]], [[3zvf]], [[3zvg]] – HEVP 68 + inhibitor <br />
+
 
 +
**[[3q3x]] – HEVP (mutant) <br />
 +
**[[3q3y]] – HEVP (mutant) + inhibitor <br />
 +
**[[3ruo]] – HEVP + drug <br />
 +
 
 +
*'''Human enterovirus protease D68'''
 +
 
 +
**[[3zv8]], [[8cnx]] – HEVP residues 1549-1731 <br />
 +
**[[8fl5]] – HEVP (mutant) <br />
 +
**[[3zv9]], [[3zva]], [[3zvb]], [[3zvc]], [[3zvd]], [[3zve]], [[3zvf]], [[3zvg]], [[7gnv]], [[7gnw]], [[7gnx]], [[7gny]], [[7gnz]], [[7go0]], [[7go1]], [[7go2]], [[7go3]], [[7go4]], [[7go5]], [[7go6]], [[7go7]], [[7go8]], [[7go9]], [[7goa]], [[7gob]], [[7goc]], [[7god]], [[7goe]], [[7gof]], [[7gog]], [[7goh]], [[7goi]], [[7goj]], [[7gok]], [[7gol]], [[7gom]], [[7gon]], [[7goo]], [[7gop]], [[7goq]], [[7gor]], [[7got]], [[7gou]], [[7gov]], [[7gow]], [[7gox]], [[7goy]], [[7goz]], [[7gp0]], [[7gp1]], [[7gp2]], [[7gp3]], [[7gp4]], [[7gp5]], [[7gp6]], [[7gp7]], [[7gp8]], [[7gp9]], [[7gpa]], [[7gpc]], [[7gpd]], [[7gpe]], [[7gpf]], [[7gpg]], [[7gph]], [[7gpi]], [[7gpj]], [[7gpl]], [[7gpm]], [[7gpn]], [[7gpo]], [[7gpp]], [[7gpq]], [[7gpr]], [[7gps]], [[7gpt]], [[7gpu]], [[7gpv]], [[7gpw]], [[7gpx]], [[7gpy]], [[7gpz]], [[7gq0]], [[7gq1]], [[7gq2]], [[7gq3]], [[7gq4]], [[7gq6]], [[7gq7]], [[7gq8]], [[7gq9]], [[7gqa]], [[7gqb]], [[7gqc]], [[7gqd]], [[7gqe]], [[7gqf]], [[7gqh]], [[7gqi]], [[7gqj]], [[7gqk]], [[7gql]], [[7gqm]], [[7gqn]], [[7gqo]], [[7gqp]], [[7gqq]], [[7gqr]] – HEVP + inhibitor <br />
 +
**[[7l8h]] – HEVP + drug <br />
*'''Porcine epidemic diarrhea virus protease'''
*'''Porcine epidemic diarrhea virus protease'''
-
**[[5hyo]], [[6noz]] – PEDVP – porcine epidemic diarrhea virus <br />
+
**[[4xfq]], [[5hyo]], [[6noz]] – PEDVP – porcine epidemic diarrhea virus <br />
 +
**[[6l70]] – PEDVP + inhibitor<br />
 +
**[[4zuh]] – PEDVP (mutant)+ inhibitor<br />
-
*'''Coronavirus protease'''
+
*'''Echovirus 1 protease'''
-
**[[4wme]], [[4wmf]] – CVP (mutant)- coronavirus <br />
+
**[[5iyt]] – EV1P (mutant) + inhibitor – Echovirus 1 <br />
-
*'''SARS coronavirus protease'''
+
*'''Transmissible Gastroenteritis virus protease'''
-
**[[3e91]], [[3ea7]], [[3ea8]], [[3ea9]], [[3eaj]] – SCVP (mutant) – SARS coronavirus <br />
+
**[[2amp]] – TGEVP + inhibitor <br />
-
**[[2amd]], [[2amq]], [[2gx4]], [[2z9g]], [[2z9j]], [[2z9k]], [[2z9l]], [[2zu5]], [[4mds]], [[4tww]], [[4twy]] – SCVP + inhibitor <br />
+
-
*'''SARS CoV-2 protease'''
+
*'''Southampton virus protease'''
-
**[[6y84]] – COV-19 <br />
+
**[[6t1q]] – SVP – Southampton virus <br />
-
**[[6yb7]] – COV-19 + inhibitor <br />
+
**[[2iph]], [[6t2i]], [[6t2x]], [[6t3g]], [[6t49]], [[6t4e]], [[6t4s]], [[6t5d]], [[6t5r]], [[6t6w]], [[6t71]], [[6t82]], [[6t8r]], [[6t8t]], [[6tal]], [[6taw]], [[6tbo]], [[6tbp]], [[6tc1]], [[6tcf]], [[6tgl]] – SVP + inhibitor<br />
-
**[[6lu7]] – COV-19 + inhibitor <br />
+
-
*'''Murine coronavirus protease'''
+
*'''West Nile virus protease'''
-
**[[6jij]] – MCP + peptide inhibitor <br />
+
**[[2ggv]] - WNVP Ns2B/Ns3 (mutant) - West Nile virus<br />
 +
**[[2ijo]] - WNVP Ns2B/Ns3 (mutant) + BPTI<br />
 +
**[[2yol]], [[5idk]], [[2fp7]] - WNVP Ns2B/Ns3 + peptide inhibitor<br />
 +
**[[3e90]] - WNVP Ns2B/Ns3 + inhibitor<br />
-
*'''Coronavirus HKU4 protease'''
+
*'''African swine fever virus protease'''
-
**[[2ynb]] – CVHP + inhibitor – BAT coronavirus <br />
+
**[[6ljb]], [[6lj9]] – ASFV – African swine fever virus<br />
-
*'''Echovirus 1 protease'''
+
*'''Senecavirus 3C protease residues 1509-1719'''
-
**[[5iyt]] – EV1P (mutant) + inhibitor – Echovirus 1 <br />
+
**[[6l0t]] – 3CP<br />
-
*'''Norovirus protease'''
+
*'''Norovirus 3C-like protease residues 1-173'''
-
**[[5e0g]], [[5e0h]], [[5e0j]] – NVP (mutant)+ peptide inhibitor – Norovirus <br />
+
**[[1wqs]] – 3CLP<br />
-
**[[3ur9]], [[4imq]], [[4xbb]], [[4xbc]], [[4xbd]], [[5dg6]], [[5dgj]], [[5tg1]], [[5tg2]] – NVP residues 1101-1281 + inhibitor <br />
+
-
*'''Norovirus 3C-like protease'''
+
*'''Norovirus 3C-like protease residues 1101-1281'''
-
**[[1wqs]] – NVLP – chiba virus <br />
+
**[[2fyq]], [[2fyr]], [[3ur6]] – 3CLP<br />
 +
**[[2lnc]] – 3CLP - NMR<br />
 +
**[[2iph]], [[3ur9]], [[4imq]] – 3CLP + peptide inhibitor<br />
 +
**[[3ur9]], [[4imz]], [[4in1]], [[4in2]], [[4inh]], [[4xbb]], [[4xbc]], [[4xbd]], [[5t61]], [[5t62]], [[5t6d]], [[5t6f]], [[5t6g]], [[5wej]], [[6w5h]], [[6w5j]], [[6w5k]], [[6w5l]] – 3CLP + inhibitor <br />
 +
**[[5dg6]], [[5dgj]], [[5e0g]], [[5e0h]], [[5e0j]], [[5tg1]], [[5tg2]], [[6bib]], [[6bic]], [[6bid]] – 3CLP + macrocyclic inhibitor <br />
 +
**[[6b6i]] – 3CLP residues 982-1162 (mutant) - human norovirus GII<br />
 +
**[[6nir]] – HOV<br />
-
*'''Gastroentritis virus protease'''
+
*Mouse Norovirus protease residues 995-1177
-
**[[2amp]] – GEVP + inhibitor – gastroenteritis virus <br />
+
**[[4ash]], [[4x2w]], [[4x2x]], [[4x2y]], [[4x2v]] – NS6 (mutant)<br />
-
*'''Southampton virus protease'''
+
*'''SARS human corona virus 3C-like protease C-terminal 3241-3546'''
-
**[[2iph]] – SVP + inhibitor – Southampton virus <br />
+
**[[1q2w]], [[1uj1]], [[1uk2]], [[1uk3]], [[1z1i]], [[2a5a]], [[2bx3]], [[2c3s]], [[2bx3]], [[2bx4]], [[2duc]], [[2gt7]], [[3ebn]], [[3vb3]], [[5r8t]], [[6m2q]], [[6wqf]], [[6xb0]], [[6xb1]], [[6xb2]], [[6xhu]], [[6y2e]], [[7ar5]], [[7ar6]], [[7bro]], [[7dqz]], [[7jp1]], [[7jpy]], [[7jun]], [[7k3t]], [[7kfi]], [[7lfp]], [[7khp]] – 3CLP – SARS-COV<br />
 +
**[[1z1j]], [[2gt8]], [[2pwx]], [[2q6g]], [[2qc2]], [[2qcy]], [[3m3s]], [[3m3t]], [[3m3v]], [[3fzd]], [[3f9e]], [[3f9f]], [[3f9g]], [[3f9h]], [[3ea7]], [[3ea8]], [[3ea9]], [[3eaj]], [[3e91]], [[3ee7]], [[3aw1]], [[4hi3]], [[5b6o]], [[7joy]], [[7n6n]], [[7t2v]] – 3CLP (mutant) – SARS-COV<br />
 +
**[[2liz]] – 3CLP – SARS-COV - NMR<br />
 +
**[[6wtj]], [[6wtk]], [[6wtm]], [[6xqs]], [[6xqt]], [[6xqu]], [[7aol]], [[7b83]], [[7brp]], [[7buy]], [[7c6s]], [[7jyc]], [[7k6d]], [[7k6e]] – 3CLP + drug – hCOV-2<br />
 +
**[[3d23]] – 3CLP + inhibitor – hCOV-HKU1<br />
 +
**[[3tlo]], [[7e6l]], [[7e6m]], [[7e6n]], [[7e6r]] – NL633CLP 2940-3242 – hCOV-NL63<br />
 +
**[[5gwy]], [[7eov]] – NL633CLP + inhibitor <br />
 +
**[[1wof]], [[2amd]], [[2amq]], [[2amp]], [[2gx4]], [[2gz7]], [[2gz8]], [[2op9]], [[2ops]], [[2vj1]], [[2ynb]], [[2z94]], [[3atw]], [[3avz]], [[3d62]], [[3iwm]], [[3sn8]], [[3v3m]], [[4tww]], [[4twy]], [[4wy3]], [[5re4]], [[5re5]], [[5re6]], [[5re7]], [[5re8]], [[5re9]], [[5rea]], [[5reb]], [[5rec]], [[5red]], [[5ree]], [[5ref]], [[5reg]], [[5rep]], [[5rer]], [[5res]], [[5ret]], [[5reu]], [[5rew]], [[5rex]], [[5rey]], [[5rez]], [[5rf1]], [[5rf2]], [[5rf3]], [[5rf4]], [[5rf5]], [[5rf6]], [[5rf9]], [[5rfa]], [[5rfb]], [[5rfc]], [[5rfd]], [[5rfe]], [[5rff]], [[5rfg]], [[5rfh]], [[5rg1]], [[5rg2]], [[5rg3]], [[5rgg]], [[5rgh]], [[5rgi]], [[5rgj]], [[5rgk]], [[5rgl]], [[5rgm]], [[5rgn]], [[5rgo]], [[5rgp]], [[5rgq]], [[5rgr]], [[5rgs]], [[6lnq]], [[6lny]], [[6lo0]], [[6lu7]], [[6lze]], [[6m0k]], [[6m2n]], [[6w2a]], [[6w63]], [[6w79]], [[6wco]], [[6xhl]], [[6xhm]], [[6xhn]], [[6xho]], [[6xmk]], [[7a1u]], [[7aga]], [[7aha]], [[7amj]], [[7bqy]], [[7c6u]], [[7d1m]], [[7jkv]], [[7jpz]], [[7jq0]], [[7jq1]], [[7jq2]], [[7jq3]], [[7jq4]], [[7jq5]], [[7k0e]], [[7k0f]], [[7k0g]], [[7k0h]], [[7ldx]], [[7vic]], [[7xar]], [[8uld]] – 3CLP + inhibitor – SARS-COV<br />
 +
**[[5c5n]], [[5c5o]], [[8h6i]] – 3CLP (mutant) + inhibitor – SARS-COV<br />
 +
**[[2vj1]], [[3tit]], [[3tiu]] – 3CLP + unsaturated ester<br />
 +
**[[2zu2]], [[2zu4]], [[2zu5]], [[3aw0]], [[3tns]], [[3tnt]], [[3vb4]], [[3vb5]], [[3vb6]], [[3vb7]], [[7t2u]] – 3CLP + peptidomimetic compound<br />
 +
**[[2z9g]] – 3CLP + benzene + Hg<br />
 +
**[[2z9j]], [[2z9k]], [[2z9l]] – 3CLP + Zn compound<br />
 +
**[[1uk4]], [[2z3c]], [[2z3d]], [[2z3e]], [[2gx4]], [[3sna]], [[3snb]], [[3snc]], [[3snd]], [[3sne]], [[6xch]] – 3CLP + peptide inhibitor<br />
 +
**[[2gtb]] - 3CLP (mutant) + aza-peptide epoxide inhibitor<br />
 +
**[[2a5i]], [[2a5k]] - 3CLP + aza-peptide epoxide inhibitor<br />
 +
**[[2d2d]] – 3CLP + I2<br />
-
*'''West Nile virus protease'''
+
*'''SARS non-human corona virus 3C-like protease C-terminal'''
-
**[[2ggv]] - WNVP (mutant) - West Nile virus<br />
+
**[[4zro]] – 3CLP + inhibitor – cat COV<br />
-
**[[2ijo]] - WNVP (mutant) + BPTI<br />
+
**[[2yna]] – 3CLP + inhibitor – bat COV-HKU4<br />
-
**[[2yol]], [[5idk]], [[2fp7]] - WNVP + peptide inhibitor<br />
+
-
**[[3e90]] - WNVP + inhibitor<br />
+
-
*'''African swine fever virus protease'''
+
*'''SARS human corona virus papain-like protease C-terminal 1564-1878'''
-
**[[6ljb]], [[6lj9]] – ASFV – African swine fever virus<br />
+
**[[6w9c]] – PLpro<br />
 +
**[[7cjd]], [[7d6h]] – PLpro (mutant) <br />
 +
**[[5tl6]], [[5tl7]], [[6xa9]], [[6xaa]], [[6yva]] – PLpro (mutant) + mISG15<br />
 +
**[[3e9s]], [[3mj5]], [[7cjm]], [[7cmd]] – PLpro + inhibitor<br />
 +
**[[7e35]], [[7jrn]] – PLpro (mutant) + inhibitor<br />
 +
**[[6wuu]], [[6wx4]] – PLpro + peptide inhibitor<br />
 +
**[[4mm3]], [[5e6j]] – PLpro + ubiquitin<br />
 +
**[[4m0w]] – PLpro (mutant) + ubiquitin<br />
 +
 
 +
*'''MERS corona virus protease C-terminal 3248-3553'''
 +
 
 +
**[[5c3n]], [[5ko3]] – ORF1A<br />
 +
**[[4wmd]], [[4wme]], [[4wmf]], [[8e7t]] – ORF1A (mutant)<br />
 +
**[[4ylu]], [[5wkj]], [[5wkk]], [[5wkl]], [[5wkm]], [[6vgy]], [[6vgz]], [[6vh0]], [[6vh1]], [[6vh2]], [[6vh3]] – ORF1A + inhibitor<br />
 +
**[[4rsp]], [[7d3c]] – ORF1A + peptide inhibitor<br />
 +
**[[5zu7]], [[5zu9]], [[5zua]] – ORF1A + nucleotide<br />
 +
**[[5zub]] – ORF1A + NAD<br />
 +
**[[5hih]] – ORF1A macro domain 1109-1275<br />
 +
**[[5dus]], [[5hol]] – ORF1A macro domain + ADP-ribose<br />
 +
 
 +
*'''MERS corona virus papain-like protease domain 1480-1811'''
 +
 
 +
**[[4rez]], [[4rna]], [[5ko3]] – ORF1AB <br />
 +
**[[4r3d]], [[4rsp]] – ORF1AB + inhibitor <br />
 +
**[[4rf0]], [[4rf1]] – ORF1AB + ubiquitin/RPL40 <br />
 +
**[[5v69]], [[5v6a]] – ORF1AB + ubiquitin <br />
 +
**[[5tl6]], [[5tl7]] – ORF1AB + ubiquitin-like protein C-terminal <br />
 +
**[[4wur]] – ORF1AB (mutant) + ubiquitin <br />
 +
 
 +
*'''Mason-pfizer monkey virus protease '''
 +
 
 +
**[[7bgt]], [[7bgu]] – MPMVP + inhibitor <br />
 +
 
 +
*'''Maize rayado fino virus protease '''
 +
 
 +
**[[7mia]] – MRFVP + inhibitor <br />
 +
**[[7mic]] – MRFVP + ubiquitin<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Updated on 03-April-2024 - For a general description of the protein see Virus protease

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Jaime Prilusky

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