SARS-CoV-2 protein NSP4

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<SX viewer='molstar' load='' size='340' side='right' caption='' scene='84/842051/Sars-cov-2_nsp4/1'>
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<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='84/842051/Nsp4/1'>
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{{Theoretical_model}}
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{{Theoretical_model}} {{Template:ModelConfidence}}
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To the right is an '''[[AlphaFold]]2''' 3D model of SARS CoV-2 Protein NSP4 (length = 500 amino acids, i.e. YP_009725300.1, color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, ''i.e.'', model 1<ref name="MIT_ColabFold">[https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb MIT ColabFold]</ref>.
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[[Image:SARS-CoV-2_NSP4.gif|250px|left|thumb|'''Morph''' of the top 5 ranked [[AlphaFold]]2 models of '''SARS-CoV-2 Protein NSP4''', ''rainbow'' color coded N-C (blue to red)<ref name="MIT_ColabFold"/>.]]
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== Function ==
== Function ==
'''Non-structural protein 4 (nsp4)'''
'''Non-structural protein 4 (nsp4)'''
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Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication.<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>
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Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>.
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It helps build fluid-filled bubbles within infected cells. Inside these bubbles, parts for new copies of the virus are constructed<ref name="NY Times COVID-19">[https://www.nytimes.com/interactive/2020/04/03/science/coronavirus-genome-bad-news-wrapped-in-protein.html ''NY Times'' (3-Apr-2020) Bad News Wrapped in Protein: Inside the Coronavirus Genome]</ref>.
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== Disease ==
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== Relevance ==
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== Structural highlights ==
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== Structural Highlights ==
== See also ==
== See also ==
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[[Coronavirus_Disease 2019 (COVID-19)]]
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[[Coronavirus_Disease 2019 (COVID-19)]]<br>
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[[SARS-CoV-2_virus_proteins]]<br>
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[[COVID-19 AlphaFold2 Models]]
__NOTOC__
__NOTOC__
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</SX>
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</StructureSection>
== References ==
== References ==
<references/>
<references/>

Current revision

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. ↑ 1.0 1.1 MIT ColabFold
  2. ↑ Modeling of the SARS-COV-2 Genome
  3. ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129
  4. ↑ NY Times (3-Apr-2020) Bad News Wrapped in Protein: Inside the Coronavirus Genome

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Joel L. Sussman, Jaime Prilusky

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