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SARS-CoV-2 protein NSP6
From Proteopedia
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| - | < | + | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='84/842052/Backbone_180_color_100-b/1'> |
| - | {{Theoretical_model}} | + | {{Theoretical_model}} {{Template:ModelConfidence}} |
| + | To the right is an '''[[AlphaFold]]2''' 3D model of SARS CoV-2 Protein NSP6 (length = 290 amino acids, NCBI ID [https://www.ncbi.nlm.nih.gov/protein/YP_009725302.1 YP_009725302]) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, ''i.e.'', model 3<ref name="MIT_ColabFold">[https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb MIT ColabFold]</ref>. | ||
== Function == | == Function == | ||
'''Non-structural protein 6 (nsp6)''' | '''Non-structural protein 6 (nsp6)''' | ||
| - | Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes | + | Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes<ref name="MIT_ColabFold"/><ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>. |
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| + | [[Image:NSP6_AlphaFold2_Movie.gif|250px|left|thumb|'''Morph''' of the top 5 ranked [[AlphaFold]]2 models of '''SARS-CoV-2 Protein NSP6''', ''rainbow'' color coded N-C (blue to red)<ref name="MIT_ColabFold"/>.]] | ||
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== See also == | == See also == | ||
| - | [[Coronavirus_Disease 2019 (COVID-19)]] | + | [[Coronavirus_Disease 2019 (COVID-19)]]<br> |
| + | [[SARS-CoV-2_virus_proteins]]<br> | ||
| + | [[COVID-19 AlphaFold2 Models]] | ||
__NOTOC__ | __NOTOC__ | ||
| - | </ | + | </StructureSection> |
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
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References
- ↑ 1.0 1.1 1.2 MIT ColabFold
- ↑ Modeling of the SARS-COV-2 Genome
- ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129
