6vk0

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'''Unreleased structure'''
 
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The entry 6vk0 is ON HOLD until Paper Publication
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==CryoEM structure of Hrd1-Usa1/Der1/Hrd3 of the flipped topology==
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<StructureSection load='6vk0' size='340' side='right'caption='[[6vk0]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6vk0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VK0 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vk0 OCA], [https://pdbe.org/6vk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vk0 RCSB], [https://www.ebi.ac.uk/pdbsum/6vk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vk0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/USA1_YEAST USA1_YEAST] Scaffold protein of the endoplasmic reticulum-associated degradation (ERAD) (also known as endoplasmic reticulum quality control, ERQC) pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Has multiple functions in ERAD including recruitment of DER1 to the HRD1 ubiquitin ligase, and regulation of HRD1 activity. Involved in oligomerization of HRD1, which is required for ERAD-L, and in HRD1 autoubiquitination and degradation.<ref>PMID:16873066</ref> <ref>PMID:19898607</ref> <ref>PMID:19940128</ref> <ref>PMID:20005842</ref> <ref>PMID:21074049</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Rapoport TA]]
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[[Category: Wu X]]

Current revision

CryoEM structure of Hrd1-Usa1/Der1/Hrd3 of the flipped topology

PDB ID 6vk0

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