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| | ==NMR solution structure of soybean allergen Gly m 4== | | ==NMR solution structure of soybean allergen Gly m 4== |
| - | <StructureSection load='2k7h' size='340' side='right'caption='[[2k7h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2k7h' size='340' side='right'caption='[[2k7h]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2k7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Glycine_hispida Glycine hispida]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7H OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2K7H FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2k7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Glycine_max Glycine max]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K7H FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2k7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k7h OCA], [http://pdbe.org/2k7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k7h RCSB], [http://www.ebi.ac.uk/pdbsum/2k7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k7h ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k7h OCA], [https://pdbe.org/2k7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k7h RCSB], [https://www.ebi.ac.uk/pdbsum/2k7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k7h ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/SAM22_SOYBN SAM22_SOYBN] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Glycine hispida]] | + | [[Category: Glycine max]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Ballmer-Weber, B K]] | + | [[Category: Ballmer-Weber BK]] |
| - | [[Category: Berkner, H]] | + | [[Category: Berkner H]] |
| - | [[Category: Mittag, D]] | + | [[Category: Mittag D]] |
| - | [[Category: Neudecker, P]] | + | [[Category: Neudecker P]] |
| - | [[Category: Roesch, P]] | + | [[Category: Roesch P]] |
| - | [[Category: Schweimer, K]] | + | [[Category: Schweimer K]] |
| - | [[Category: Vieths, S]] | + | [[Category: Vieths S]] |
| - | [[Category: Allergen]]
| + | |
| - | [[Category: Pathogenesis-related protein]]
| + | |
| - | [[Category: Plant defense]]
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| - | [[Category: Protein]]
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| - | [[Category: Soybean]]
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| Structural highlights
Function
SAM22_SOYBN
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
In many cases, patients allergic to birch pollen also show allergic reactions after ingestion of certain fruits or vegetables. This observation is explained at the molecular level by cross-reactivity of IgE antibodies induced by sensitization to the major birch pollen allergen Bet v 1 with homologous food allergens. As IgE antibodies recognize conformational epitopes, a precise structural characterization of the allergens involved is necessary to understand cross-reactivity and thus to develop new methods of allergen-specific immunotherapy for allergic patients. Here, we report the three-dimensional solution structure of the soybean allergen Gly m 4, a member of the superfamily of Bet v 1 homologous proteins and a cross-reactant with IgE antibodies originally raised against Bet v 1 as shown by immunoblot inhibition and histamine release assays. Although the overall fold of Gly m 4 is very similar to that of Bet v 1, the three-dimensional structures of these proteins differ in detail. The Gly m 4 local structures that display those differences are also found in proteins from yellow lupine with known physiological function. The three-dimensional structure of Gly m 4 may thus shed some light on the physiological function of this subgroup of PR10 proteins (class 10 of pathogenesis-related proteins) and, in combination with immunological data, allow us to propose surface patches that might represent cross-reactive epitopes.
Cross-reactivity of pollen and food allergens: soybean Gly m 4 is a member of the Bet v 1 superfamily and closely resembles yellow lupine proteins.,Berkner H, Neudecker P, Mittag D, Ballmer-Weber BK, Schweimer K, Vieths S, Rosch P Biosci Rep. 2009 Jun;29(3):183-92. PMID:18834331[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Berkner H, Neudecker P, Mittag D, Ballmer-Weber BK, Schweimer K, Vieths S, Rosch P. Cross-reactivity of pollen and food allergens: soybean Gly m 4 is a member of the Bet v 1 superfamily and closely resembles yellow lupine proteins. Biosci Rep. 2009 Jun;29(3):183-92. PMID:18834331 doi:10.1042/BSR20080117
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