5e3d

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<StructureSection load='5e3d' size='340' side='right'caption='[[5e3d]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
<StructureSection load='5e3d' size='340' side='right'caption='[[5e3d]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5e3d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E3D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5E3D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5e3d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E3D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5JL:2,8-DITHIOXO-1,2,3,7,8,9-HEXAHYDRO-6H-PURIN-6-ONE'>5JL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRPF1, BR140 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5JL:2,8-DITHIOXO-1,2,3,7,8,9-HEXAHYDRO-6H-PURIN-6-ONE'>5JL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5e3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e3d OCA], [http://pdbe.org/5e3d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e3d RCSB], [http://www.ebi.ac.uk/pdbsum/5e3d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e3d ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e3d OCA], [https://pdbe.org/5e3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e3d RCSB], [https://www.ebi.ac.uk/pdbsum/5e3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e3d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Caflisch, A]]
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[[Category: Caflisch A]]
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[[Category: Zhu, J]]
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[[Category: Zhu J]]
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[[Category: Dna binding protein]]
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[[Category: Inhibitor]]
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[[Category: Transcription]]
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Current revision

Crystal structure of the human BRPF1 bromodomain in complex with SEED7

PDB ID 5e3d

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