6wlg

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(New page: '''Unreleased structure''' The entry 6wlg is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (14:45, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6wlg is ON HOLD
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==Ints3 C-terminal Domain==
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<StructureSection load='6wlg' size='340' side='right'caption='[[6wlg]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6wlg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WLG FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.111&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wlg OCA], [https://pdbe.org/6wlg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wlg RCSB], [https://www.ebi.ac.uk/pdbsum/6wlg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wlg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INT3_HUMAN INT3_HUMAN] Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.<ref>PMID:19605351</ref> <ref>PMID:19683501</ref> Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.<ref>PMID:19605351</ref> <ref>PMID:19683501</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Banerjee S]]
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[[Category: Dong ZG]]
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[[Category: Li J]]
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[[Category: Ma XL]]

Current revision

Ints3 C-terminal Domain

PDB ID 6wlg

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