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6me8

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Current revision (06:29, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6me8' size='340' side='right'caption='[[6me8]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='6me8' size='340' side='right'caption='[[6me8]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6me8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ME8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ME8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6me8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_pasteurianum Clostridium pasteurianum], [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ME8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ME8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JEY:N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide'>JEY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTNR1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JEY:N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide'>JEY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6me8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6me8 OCA], [http://pdbe.org/6me8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6me8 RCSB], [http://www.ebi.ac.uk/pdbsum/6me8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6me8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6me8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6me8 OCA], [https://pdbe.org/6me8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6me8 RCSB], [https://www.ebi.ac.uk/pdbsum/6me8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6me8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/MTR1B_HUMAN MTR1B_HUMAN] High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.[https://www.uniprot.org/uniprot/RUBR_CLOPA RUBR_CLOPA] Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Clostridium pasteurianum]]
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[[Category: Escherichia coli]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Batyuk, A]]
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[[Category: Batyuk A]]
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[[Category: Cherezov, V]]
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[[Category: Cherezov V]]
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[[Category: Gati, C]]
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[[Category: Gati C]]
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[[Category: Grandner, J]]
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[[Category: Grandner J]]
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[[Category: Han, G W]]
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[[Category: Han GW]]
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[[Category: Hao, S]]
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[[Category: Hao S]]
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[[Category: Johansson, L C]]
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[[Category: Johansson LC]]
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[[Category: Katritch, V]]
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[[Category: Katritch V]]
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[[Category: Li, C]]
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[[Category: Li C]]
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[[Category: Liu, W]]
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[[Category: Liu W]]
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[[Category: McCorvy, J]]
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[[Category: McCorvy J]]
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[[Category: Olsen, R H.J]]
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[[Category: Olsen RHJ]]
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[[Category: Patel, N]]
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[[Category: Patel N]]
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[[Category: Roth, B L]]
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[[Category: Roth BL]]
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[[Category: Stauch, B]]
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[[Category: Stauch B]]
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[[Category: Tribo, A R]]
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[[Category: Tribo AR]]
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[[Category: Weierstall, U]]
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[[Category: Weierstall U]]
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[[Category: Zaare, S]]
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[[Category: Zaare S]]
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[[Category: Zatsepin, N A]]
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[[Category: Zatsepin NA]]
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[[Category: Zhu, L]]
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[[Category: Zhu L]]
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[[Category: 2-phenylmelatonin]]
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[[Category: Bril]]
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[[Category: Circadian rhythm]]
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[[Category: Gpcr]]
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[[Category: Jetlag]]
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[[Category: Lcp]]
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[[Category: Membrane protein]]
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[[Category: N86d mutation]]
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[[Category: Rubredoxin]]
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[[Category: Type 2 diabetes]]
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[[Category: Xfel]]
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Current revision

XFEL crystal structure of human melatonin receptor MT2 (N86D) in complex with 2-phenylmelatonin

PDB ID 6me8

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