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5eyx

From Proteopedia

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Current revision (08:34, 12 July 2023) (edit) (undo)
 
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<StructureSection load='5eyx' size='340' side='right'caption='[[5eyx]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='5eyx' size='340' side='right'caption='[[5eyx]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5eyx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Centrolobium_tomentosum Centrolobium tomentosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EYX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EYX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5eyx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Centrolobium_tomentosum Centrolobium tomentosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EYX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MDM:METHYL-O3-(ALPHA-D-MANNOSE)-ALPHA-D-MANNOSE'>MDM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eyy|5eyy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5eyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eyx OCA], [http://pdbe.org/5eyx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eyx RCSB], [http://www.ebi.ac.uk/pdbsum/5eyx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eyx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eyx OCA], [https://pdbe.org/5eyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eyx RCSB], [https://www.ebi.ac.uk/pdbsum/5eyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eyx ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LECC1_CENTO LECC1_CENTO] Mannose/glucose-specific lectin that also binds derivatives N-acetyl-D-glucosamine and alpha-methyl-D-mannopyranoside with even higher affinity (Ref.2, PubMed:26946944). Has hemagglutinating activity towards rabbit erythrocytes (Ref.2). Is toxic towards brine shrimp A.nauplii (Ref.2). In rats, induces dose-dependent paw edema (PubMed:26946944).<ref>PMID:26946944</ref> [REFERENCE:2]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Centrolobium tomentosum]]
[[Category: Centrolobium tomentosum]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Almeida, A C]]
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[[Category: Almeida AC]]
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[[Category: Almeida, R P.H]]
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[[Category: Almeida RPH]]
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[[Category: Cavada, B S]]
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[[Category: Cavada BS]]
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[[Category: Delatorre, P]]
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[[Category: Delatorre P]]
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[[Category: Lossio, C F]]
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[[Category: Lossio CF]]
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[[Category: Osterne, V J.S]]
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[[Category: Osterne VJS]]
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[[Category: Pinto-Junior, V R]]
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[[Category: Pinto-Junior VR]]
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[[Category: Rocha, B A.M]]
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[[Category: Rocha BAM]]
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[[Category: Santiago, K S]]
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[[Category: Santiago KS]]
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[[Category: Santiago, M Q]]
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[[Category: Santiago MQ]]
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[[Category: Silva-Filho, J C]]
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[[Category: Silva-Filho JC]]
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[[Category: Teixeira, C S]]
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[[Category: Teixeira CS]]
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[[Category: Ctl]]
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[[Category: Dalbergieae]]
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[[Category: Lectin]]
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[[Category: Methyl dimannoside]]
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[[Category: Sugar binding protein]]
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Current revision

Monoclinic Form of Centrolobium tomentosum seed lectin (CTL) complexed with Man1-3Man-OMe.

PDB ID 5eyx

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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