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5f3a
From Proteopedia
(Difference between revisions)
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<StructureSection load='5f3a' size='340' side='right'caption='[[5f3a]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='5f3a' size='340' side='right'caption='[[5f3a]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5f3a]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5f3a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F3A FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.599Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5U9:~{N}-(4-ETHANOYL-1,3-THIAZOL-2-YL)AZETIDIN-1-IUM-3-CARBOXAMIDE'>5U9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f3a OCA], [https://pdbe.org/5f3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f3a RCSB], [https://www.ebi.ac.uk/pdbsum/5f3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f3a ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref> |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | + | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Caflisch | + | [[Category: Caflisch A]] |
| - | [[Category: Dong | + | [[Category: Dong J]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of the bromodomain of human ATAD2 in complex with Compound A14
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