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| | <StructureSection load='5f70' size='340' side='right'caption='[[5f70]], [[Resolution|resolution]] 1.80Å' scene=''> | | <StructureSection load='5f70' size='340' side='right'caption='[[5f70]], [[Resolution|resolution]] 1.80Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5f70]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F70 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5F70 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5f70]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F70 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f71|5f71]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIMD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f70 OCA], [https://pdbe.org/5f70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f70 RCSB], [https://www.ebi.ac.uk/pdbsum/5f70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f70 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5f70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f70 OCA], [http://pdbe.org/5f70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f70 RCSB], [http://www.ebi.ac.uk/pdbsum/5f70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f70 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/HAVR1_HUMAN HAVR1_HUMAN]] May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair.<ref>PMID:17471468</ref> (Microbial infection) Acts as a receptor for hepatitis A virus (PubMed:9658108). Acts as a receptor for ebolavirus and marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921).<ref>PMID:21536871</ref> <ref>PMID:23084921</ref> <ref>PMID:9658108</ref> | + | [https://www.uniprot.org/uniprot/HAVR1_HUMAN HAVR1_HUMAN] May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair.<ref>PMID:17471468</ref> (Microbial infection) Acts as a receptor for hepatitis A virus (PubMed:9658108). Acts as a receptor for ebolavirus and marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921).<ref>PMID:21536871</ref> <ref>PMID:23084921</ref> <ref>PMID:9658108</ref> |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Gao, G F]] | + | [[Category: Gao GF]] |
| - | [[Category: Lu, G]] | + | [[Category: Lu G]] |
| - | [[Category: Qi, J]] | + | [[Category: Qi J]] |
| - | [[Category: Wang, H]] | + | [[Category: Wang H]] |
| - | [[Category: Ebola virus]]
| + | |
| - | [[Category: Htim]]
| + | |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: Receptor]]
| + | |
| Structural highlights
Function
HAVR1_HUMAN May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair.[1] (Microbial infection) Acts as a receptor for hepatitis A virus (PubMed:9658108). Acts as a receptor for ebolavirus and marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921).[2] [3] [4]
References
- ↑ van Timmeren MM, van den Heuvel MC, Bailly V, Bakker SJ, van Goor H, Stegeman CA. Tubular kidney injury molecule-1 (KIM-1) in human renal disease. J Pathol. 2007 Jun;212(2):209-17. PMID:17471468 doi:http://dx.doi.org/10.1002/path.2175
- ↑ Kondratowicz AS, Lennemann NJ, Sinn PL, Davey RA, Hunt CL, Moller-Tank S, Meyerholz DK, Rennert P, Mullins RF, Brindley M, Sandersfeld LM, Quinn K, Weller M, McCray PB Jr, Chiorini J, Maury W. T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8426-31. doi:, 10.1073/pnas.1019030108. Epub 2011 May 2. PMID:21536871 doi:http://dx.doi.org/10.1073/pnas.1019030108
- ↑ Meertens L, Carnec X, Lecoin MP, Ramdasi R, Guivel-Benhassine F, Lew E, Lemke G, Schwartz O, Amara A. The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry. Cell Host Microbe. 2012 Oct 18;12(4):544-57. doi: 10.1016/j.chom.2012.08.009. PMID:23084921 doi:http://dx.doi.org/10.1016/j.chom.2012.08.009
- ↑ Feigelstock D, Thompson P, Mattoo P, Zhang Y, Kaplan GG. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J Virol. 1998 Aug;72(8):6621-8. PMID:9658108
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