General secretion pathway protein
From Proteopedia
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| - | < | + | <SX viewer='molstar' load='6hcg' size='340' side='right' caption='PulC + PulD + PulS complex (PDB code [[6hcg]])' scene=''> |
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== Function == | == Function == | ||
| - | '''General secretion pathway | + | '''General secretion pathway proteins''' (Eps) are used by gram-negative pathogenic bacteria to transport their virulence factors outside of the cell via '''type II secretion system''' or T2SS. Examples are the transport of cholera toxin by ''Vibrio cholerae'' and exotoxin A by ''Pseudomonas aeruginosa''<ref>PMID:26999395</ref>. In ''Pseudomonas aeruginosa'' the Eps are named Xcp. EpsG,H,I,J,K are named PulG, PulH, PulI, PulJ, PulK. See [[Pseudopilin]]. |
| - | == | + | == Structural highlights == |
| - | + | The 3D structure of the bacterial core shows a 15-fold rotationally symmetric PulD called secretin which inserts into the cell membrane and enables conductance of substrate intothe external environment<ref>PMID:31780649</ref>. | |
| - | == Structural highlights == | ||
| - | + | </SX> | |
| - | </StructureSection> | ||
==3D structures of general secretion pathway protein== | ==3D structures of general secretion pathway protein== | ||
| + | [[General secretion pathway protein 3D structures]] | ||
| - | *General secretion pathway protein C | ||
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| - | **[[2i4s]], [[2i6v]] - VcEpsC PDZ domain 204-305 - ''Vibrio cholerae''<br /> | ||
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| - | *General secretion pathway protein E+L | ||
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| - | **[[2bh1]] - VcEpsE residues 1-96 + VcEpsL residues 5-246<br /> | ||
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| - | *General secretion pathway protein F | ||
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| - | **[[5nbg]] - EpsF residues 65-172 - ''Dickeya dadantii''<br /> | ||
| - | **[[2vma]] - VcEpsF residues 56-170 <br /> | ||
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| - | *General secretion pathway protein L | ||
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| - | **[[1yf5]], [[1w97]] - VcEpsL cytoplasmic domain 1-248 <br /> | ||
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| - | *General secretion pathway protein M | ||
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| - | **[[1uv7]] - VcEpsM periplasmic domain 65-165<br /> | ||
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| - | *General secretion pathway protein G,H,I,J,K see [[Pseudopilin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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3D structures of general secretion pathway protein
General secretion pathway protein 3D structures
References
- ↑ Green ER, Mecsas J. Bacterial Secretion Systems: An Overview. Microbiol Spectr. 2016 Feb;4(1). doi: 10.1128/microbiolspec.VMBF-0012-2015. PMID:26999395 doi:http://dx.doi.org/10.1128/microbiolspec.VMBF-0012-2015
- ↑ Chernyatina AA, Low HH. Core architecture of a bacterial type II secretion system. Nat Commun. 2019 Nov 28;10(1):5437. doi: 10.1038/s41467-019-13301-3. PMID:31780649 doi:http://dx.doi.org/10.1038/s41467-019-13301-3
