General secretion pathway protein

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<StructureSection load='6hcg' size='340' side='right' caption='PulC + PulD + PulS complex (PDB code [[6hcg]])' scene=''>
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<SX viewer='molstar' load='6hcg' size='340' side='right' caption='PulC + PulD + PulS complex (PDB code [[6hcg]])' scene=''>
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== Function ==
== Function ==
'''General secretion pathway proteins''' (Eps) are used by gram-negative pathogenic bacteria to transport their virulence factors outside of the cell via '''type II secretion system''' or T2SS. Examples are the transport of cholera toxin by ''Vibrio cholerae'' and exotoxin A by ''Pseudomonas aeruginosa''<ref>PMID:26999395</ref>. In ''Pseudomonas aeruginosa'' the Eps are named Xcp. EpsG,H,I,J,K are named PulG, PulH, PulI, PulJ, PulK. See [[Pseudopilin]].
'''General secretion pathway proteins''' (Eps) are used by gram-negative pathogenic bacteria to transport their virulence factors outside of the cell via '''type II secretion system''' or T2SS. Examples are the transport of cholera toxin by ''Vibrio cholerae'' and exotoxin A by ''Pseudomonas aeruginosa''<ref>PMID:26999395</ref>. In ''Pseudomonas aeruginosa'' the Eps are named Xcp. EpsG,H,I,J,K are named PulG, PulH, PulI, PulJ, PulK. See [[Pseudopilin]].
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== Disease ==
 
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== Relevance ==
 
== Structural highlights ==
== Structural highlights ==
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The 3D structure of the bacterial core shows a 15-fold rotationally symmetric PulD called secretin which inserts into the cell membrane and enables conductance of substrate intothe external environment<ref>PMID:31780649</ref>.
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</StructureSection>
 
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==3D structures of general secretion pathway protein==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*General secretion pathway protein AB
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</SX>
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**[[4g54]] - VvEpsD residues 326-584 - ''Vibrio vulnificus''<br />
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==3D structures of general secretion pathway protein==
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[[General secretion pathway protein 3D structures]]
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*General secretion pathway protein B
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**[[4wfw]] - DdEpsB residues 112-201 - ''Dickeya dadantii''<br />
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*General secretion pathway protein C
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**[[2i4s]], [[2i6v]] - VcEpsC PDZ domain 204-305 - ''Vibrio cholerae''<br />
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**[[2lnv]] - DdEpsC residues 77-172<br />
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*General secretion pathway protein C+D+S
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**[[6hcg]] - KpEpsC + EpsD + EpsS - ''Klebsiella pneumoniae'' - Cryo EM<br />
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*General secretion pathway protein D
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**[[6i1y]] - VvEpsD residues 121-673 - Cryo EM<br />
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**[[3ezj]] - EpsD N-terminal 40-277 + nanobody - ''Eschericia coli''<br />
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**[[4e9j]] - PaEpsD N-terminal 35-277 - ''Pseudomonas aeruginosa''<br />
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**[[4ec5]] - PaEpsD N-terminal (mutant)<br />
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**[[5wln]] - PaEpsD residues 35-658 - Cryo EM<br />
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**[[6i1x]] - EpsD residues 122-645 - ''Aeromonas hydrophila'' - Cryo EM<br />
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*General secretion pathway protein E
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**[[1p9w]], [[1p9r]] - VcEpsE residues 1-90 <br />
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**[[4ksr]], [[4kss]] - VcEpsE residues 100-503 <br />
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*General secretion pathway protein E+L
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**[[2bh1]] - VcEpsE residues 1-96 + VcEpsL residues 5-246<br />
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*General secretion pathway protein F
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**[[5nbg]] - DdEpsF residues 65-172<br />
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**[[2vma]], [[2vmb]], [[3c1q]] - VcEpsF residues 56-170 <br />
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*General secretion pathway protein L
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**[[1yf5]], [[1w97]] - VcEpsL cytoplasmic domain 1-248 <br />
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**[[2w7v]] - EpsL periplasmic domain 319-404 - ''Vibrio parahaemolyticus''<br />
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**[[5n7l]] - PaEpsL periplasmic domain 303-382 <br />
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**[[5hl8]] - KpEpsL C-terminal domain 309-397 <br />
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*General secretion pathway protein M
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**[[1uv7]] - VcEpsM periplasmic domain 65-165<br />
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*General secretion pathway protein G,H,I,J,K see [[Pseudopilin]]
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

PulC + PulD + PulS complex (PDB code 6hcg)

3D structures of general secretion pathway protein

General secretion pathway protein 3D structures

References

  1. ↑ Green ER, Mecsas J. Bacterial Secretion Systems: An Overview. Microbiol Spectr. 2016 Feb;4(1). doi: 10.1128/microbiolspec.VMBF-0012-2015. PMID:26999395 doi:http://dx.doi.org/10.1128/microbiolspec.VMBF-0012-2015
  2. ↑ Chernyatina AA, Low HH. Core architecture of a bacterial type II secretion system. Nat Commun. 2019 Nov 28;10(1):5437. doi: 10.1038/s41467-019-13301-3. PMID:31780649 doi:http://dx.doi.org/10.1038/s41467-019-13301-3

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky

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