7c0m
From Proteopedia
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(New page: '''Unreleased structure''' The entry 7c0m is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Human cGAS-nucleosome complex== | |
| + | <StructureSection load='7c0m' size='340' side='right'caption='[[7c0m]], [[Resolution|resolution]] 3.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7c0m]] is a 22 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C0M FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c0m OCA], [https://pdbe.org/7c0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c0m RCSB], [https://www.ebi.ac.uk/pdbsum/7c0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c0m ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]] | |
| - | + | *[[Histone 3D structures|Histone 3D structures]] | |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Funabiki H]] | ||
| + | [[Category: Hirai S]] | ||
| + | [[Category: Kim R]] | ||
| + | [[Category: Kujirai T]] | ||
| + | [[Category: Kurumizaka H]] | ||
| + | [[Category: Negishi L]] | ||
| + | [[Category: Takizawa Y]] | ||
| + | [[Category: Uruma N]] | ||
| + | [[Category: Zierhut C]] | ||
Current revision
Human cGAS-nucleosome complex
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Categories: Homo sapiens | Large Structures | Synthetic construct | Funabiki H | Hirai S | Kim R | Kujirai T | Kurumizaka H | Negishi L | Takizawa Y | Uruma N | Zierhut C
