We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
1b8w
From Proteopedia
(Difference between revisions)
| (12 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1b8w.jpg|left|200px]] | ||
| - | < | + | ==DEFENSIN-LIKE PEPTIDE 1== |
| - | + | <StructureSection load='1b8w' size='340' side='right'caption='[[1b8w]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1b8w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ornithorhynchus_anatinus Ornithorhynchus anatinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B8W FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |
| - | --> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8w OCA], [https://pdbe.org/1b8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b8w RCSB], [https://www.ebi.ac.uk/pdbsum/1b8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8w ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/DLP1_ORNAN DLP1_ORNAN] Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities.<ref>PMID:10417345</ref> | |
| - | + | <div style="background-color:#fffaf0;"> | |
| - | + | == Publication Abstract from PubMed == | |
| - | == | + | |
Three defensin-like peptides (DLPs) were isolated from platypus venom and sequenced. One of these peptides, DLP-1, was synthesized chemically and its three-dimensional structure was determined using NMR spectroscopy. The main structural elements of this 42-residue peptide were an anti-parallel beta-sheet comprising residues 15-18 and 37-40 and a small 3(10) helix spanning residues 10-12. The overall three-dimensional fold is similar to that of beta-defensin-12, and similar to the sodium-channel neurotoxin ShI (Stichodactyla helianthus neurotoxin I). However, the side chains known to be functionally important in beta-defensin-12 and ShI are not conserved in DLP-1, suggesting that it has a different biological function. Consistent with this contention, we showed that DLP-1 possesses no anti-microbial properties and has no observable activity on rat dorsal-root-ganglion sodium-channel currents. | Three defensin-like peptides (DLPs) were isolated from platypus venom and sequenced. One of these peptides, DLP-1, was synthesized chemically and its three-dimensional structure was determined using NMR spectroscopy. The main structural elements of this 42-residue peptide were an anti-parallel beta-sheet comprising residues 15-18 and 37-40 and a small 3(10) helix spanning residues 10-12. The overall three-dimensional fold is similar to that of beta-defensin-12, and similar to the sodium-channel neurotoxin ShI (Stichodactyla helianthus neurotoxin I). However, the side chains known to be functionally important in beta-defensin-12 and ShI are not conserved in DLP-1, suggesting that it has a different biological function. Consistent with this contention, we showed that DLP-1 possesses no anti-microbial properties and has no observable activity on rat dorsal-root-ganglion sodium-channel currents. | ||
| - | + | Solution structure of a defensin-like peptide from platypus venom.,Torres AM, Wang X, Fletcher JI, Alewood D, Alewood PF, Smith R, Simpson RJ, Nicholson GM, Sutherland SK, Gallagher CH, King GF, Kuchel PW Biochem J. 1999 Aug 1;341 ( Pt 3):785-94. PMID:10417345<ref>PMID:10417345</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| + | <div class="pdbe-citations 1b8w" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Ornithorhynchus anatinus]] | [[Category: Ornithorhynchus anatinus]] | ||
| - | + | [[Category: Alewood D]] | |
| - | [[Category: Alewood | + | [[Category: Alewood PF]] |
| - | [[Category: Alewood | + | [[Category: Fletcher JI]] |
| - | [[Category: Fletcher | + | [[Category: Gallagher CH]] |
| - | [[Category: Gallagher | + | [[Category: King GF]] |
| - | [[Category: King | + | [[Category: Kuchel PW]] |
| - | [[Category: Kuchel | + | [[Category: Nicholson GM]] |
| - | [[Category: Nicholson | + | [[Category: Simpson RJ]] |
| - | [[Category: Simpson | + | [[Category: Smith R]] |
| - | [[Category: Smith | + | [[Category: Sutherland SK]] |
| - | [[Category: Sutherland | + | [[Category: Torres AM]] |
| - | [[Category: Torres | + | [[Category: Wang X]] |
| - | [[Category: Wang | + | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
DEFENSIN-LIKE PEPTIDE 1
| |||||||||||
