6ym0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:45, 23 October 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 3: Line 3:
<StructureSection load='6ym0' size='340' side='right'caption='[[6ym0]], [[Resolution|resolution]] 4.36&Aring;' scene=''>
<StructureSection load='6ym0' size='340' side='right'caption='[[6ym0]], [[Resolution|resolution]] 4.36&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6ym0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Wcpv Wcpv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YM0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YM0 FirstGlance]. <br>
+
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YM0 FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6yla|6yla]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.36&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S, 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2697049 WCPV])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ym0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ym0 OCA], [https://pdbe.org/6ym0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ym0 RCSB], [https://www.ebi.ac.uk/pdbsum/6ym0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ym0 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ym0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ym0 OCA], [http://pdbe.org/6ym0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ym0 RCSB], [http://www.ebi.ac.uk/pdbsum/6ym0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ym0 ProSAT]</span></td></tr>
+
</table>
</table>
-
== Function ==
+
 
-
[[http://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
+
==See Also==
-
== References ==
+
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Wcpv]]
+
[[Category: Fry EE]]
-
[[Category: Fry, E E]]
+
[[Category: Ginn HM]]
-
[[Category: Ginn, H M]]
+
[[Category: Huo J]]
-
[[Category: Huo, J]]
+
[[Category: Owens R]]
-
[[Category: Owens, R]]
+
[[Category: Ren J]]
-
[[Category: Ren, J]]
+
[[Category: Stuart DI]]
-
[[Category: Stuart, D I]]
+
[[Category: Zhao Y]]
-
[[Category: Zhao, Y]]
+
[[Category: Zhou D]]
-
[[Category: Zhou, D]]
+
-
[[Category: Cr3022]]
+
-
[[Category: Sars-cov-2]]
+
-
[[Category: Vagabond]]
+
-
[[Category: Viral protein]]
+

Current revision

Crystal structure of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab (crystal form 1)

PDB ID 6ym0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6ym0"
Personal tools