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2l5i

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==structure of the spliceosomal phosphopeptide P140 (non-phosphorylated form)==
==structure of the spliceosomal phosphopeptide P140 (non-phosphorylated form)==
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<StructureSection load='2l5i' size='340' side='right'caption='[[2l5i]], [[NMR_Ensembles_of_Models | 8 NMR models]]' scene=''>
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<StructureSection load='2l5i' size='340' side='right'caption='[[2l5i]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l5i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2L5I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L5I FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2l5j|2l5j]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2l5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l5i OCA], [http://pdbe.org/2l5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l5i RCSB], [http://www.ebi.ac.uk/pdbsum/2l5i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l5i ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l5i OCA], [https://pdbe.org/2l5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l5i RCSB], [https://www.ebi.ac.uk/pdbsum/2l5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l5i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RU17_HUMAN RU17_HUMAN]] Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
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[https://www.uniprot.org/uniprot/RU17_HUMAN RU17_HUMAN] Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The phosphopeptide P140 issued from the spliceosomal U1-70K snRNP protein is recognized by lupus CD4(+) T cells, transiently abolishes T cell reactivity to other spliceosomal peptides in P140-treated MRL/lpr mice, and ameliorates their clinical features. P140 modulates lupus patients' T cell response ex vivo and is currently included in phase IIb clinical trials. Its underlying mechanism of action remains elusive. Here we show that P140 peptide binds a unique cell-surface receptor, the constitutively-expressed chaperone HSC70 protein, known as a presenting-protein. P140 induces apoptosis of activated MRL/lpr CD4(+) T cells. In P140-treated mice, it increases peripheral blood lymphocyte apoptosis and decreases B cell, activated T cell, and CD4(-)CD8(-)B220(+) T cell counts via a specific mechanism strictly depending on gammadelta T cells. Expression of inflammation-linked genes is rapidly regulated in CD4(+) T cells. This work led us to identify a powerful pathway taken by a newly-designed therapeutic peptide to immunomodulate lupus autoimmunity.
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The spliceosomal phosphopeptide P140 controls the lupus disease by interacting with the HSC70 protein and via a mechanism mediated by gammadelta T cells.,Page N, Schall N, Strub JM, Quinternet M, Chaloin O, Decossas M, Cung MT, Van Dorsselaer A, Briand JP, Muller S PLoS One. 2009;4(4):e5273. Epub 2009 Apr 23. PMID:19390596<ref>PMID:19390596</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2l5i" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Briand, J]]
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[[Category: Briand J]]
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[[Category: Chaloin, O]]
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[[Category: Chaloin O]]
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[[Category: Cung, M]]
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[[Category: Cung M]]
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[[Category: Decossas, M]]
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[[Category: Decossas M]]
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[[Category: Dorsselaer, A van]]
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[[Category: Muller S]]
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[[Category: Muller, S]]
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[[Category: Page N]]
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[[Category: Page, N]]
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[[Category: Quinternet M]]
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[[Category: Quinternet, M]]
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[[Category: Schall N]]
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[[Category: Schall, N]]
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[[Category: Strub J]]
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[[Category: Strub, J]]
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[[Category: Van Dorsselaer A]]
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[[Category: Hsc70]]
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[[Category: Lupus]]
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[[Category: Phosphorylation]]
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[[Category: Splicing]]
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Current revision

structure of the spliceosomal phosphopeptide P140 (non-phosphorylated form)

PDB ID 2l5i

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