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| | ==Structure of the NOXO1b PX domain== | | ==Structure of the NOXO1b PX domain== |
| - | <StructureSection load='2l73' size='340' side='right'caption='[[2l73]], [[NMR_Ensembles_of_Models | 14 NMR models]]' scene=''> | + | <StructureSection load='2l73' size='340' side='right'caption='[[2l73]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2l73]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L73 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2L73 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2l73]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L73 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2l73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l73 OCA], [http://pdbe.org/2l73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l73 RCSB], [http://www.ebi.ac.uk/pdbsum/2l73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l73 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l73 OCA], [https://pdbe.org/2l73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l73 RCSB], [https://www.ebi.ac.uk/pdbsum/2l73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l73 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/NOXO1_HUMAN NOXO1_HUMAN]] Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.<ref>PMID:12657628</ref> <ref>PMID:14617635</ref> <ref>PMID:15949904</ref> <ref>PMID:15326186</ref> <ref>PMID:15824103</ref> <ref>PMID:16329988</ref> <ref>PMID:17126813</ref> <ref>PMID:19755710</ref> | + | [https://www.uniprot.org/uniprot/NOXO1_HUMAN NOXO1_HUMAN] Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.<ref>PMID:12657628</ref> <ref>PMID:14617635</ref> <ref>PMID:15949904</ref> <ref>PMID:15326186</ref> <ref>PMID:15824103</ref> <ref>PMID:16329988</ref> <ref>PMID:17126813</ref> <ref>PMID:19755710</ref> |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Davis, N Y]] | + | [[Category: Davis NY]] |
| - | [[Category: Horita, D A]] | + | [[Category: Horita DA]] |
| - | [[Category: McPhail, L C]] | + | [[Category: McPhail LC]] |
| - | [[Category: Cell membrane]]
| + | |
| - | [[Category: Oxidoreductase regulator]]
| + | |
| - | [[Category: Px domain]]
| + | |
| Structural highlights
Function
NOXO1_HUMAN Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.[1] [2] [3] [4] [5] [6] [7] [8]
References
- ↑ Geiszt M, Lekstrom K, Witta J, Leto TL. Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J Biol Chem. 2003 May 30;278(22):20006-12. Epub 2003 Mar 25. PMID:12657628 doi:http://dx.doi.org/10.1074/jbc.M301289200
- ↑ Cheng G, Lambeth JD. NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. J Biol Chem. 2004 Feb 6;279(6):4737-42. Epub 2003 Nov 14. PMID:14617635 doi:http://dx.doi.org/10.1074/jbc.M305968200
- ↑ Cheng G, Lambeth JD. Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3. Gene. 2005 Aug 15;356:118-26. PMID:15949904 doi:http://dx.doi.org/10.1016/j.gene.2005.03.008
- ↑ Banfi B, Malgrange B, Knisz J, Steger K, Dubois-Dauphin M, Krause KH. NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem. 2004 Oct 29;279(44):46065-72. Epub 2004 Aug 23. PMID:15326186 doi:http://dx.doi.org/10.1074/jbc.M403046200
- ↑ Ueno N, Takeya R, Miyano K, Kikuchi H, Sumimoto H. The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators. J Biol Chem. 2005 Jun 17;280(24):23328-39. Epub 2005 Apr 11. PMID:15824103 doi:10.1074/jbc.M414548200
- ↑ Park HS, Park D, Bae YS. Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1. Biochem Biophys Res Commun. 2006 Jan 20;339(3):985-90. PMID:16329988 doi:http://dx.doi.org/10.1016/j.bbrc.2005.11.108
- ↑ Yamamoto A, Kami K, Takeya R, Sumimoto H. Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1). Biochem Biophys Res Commun. 2007 Jan 12;352(2):560-5. Epub 2006 Nov 20. PMID:17126813 doi:http://dx.doi.org/10.1016/j.bbrc.2006.11.060
- ↑ Gianni D, Diaz B, Taulet N, Fowler B, Courtneidge SA, Bokoch GM. Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal. 2009 Sep 15;2(88):ra54. doi: 10.1126/scisignal.2000370. PMID:19755710 doi:http://dx.doi.org/10.1126/scisignal.2000370
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