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5fhz

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Current revision (06:51, 19 July 2023) (edit) (undo)
 
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<StructureSection load='5fhz' size='340' side='right'caption='[[5fhz]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='5fhz' size='340' side='right'caption='[[5fhz]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fhz]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FHZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FHZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fhz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FHZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALDH1A3, ALDH6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(NAD(P)(+)) Aldehyde dehydrogenase (NAD(P)(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.5 1.2.1.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fhz OCA], [https://pdbe.org/5fhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fhz RCSB], [https://www.ebi.ac.uk/pdbsum/5fhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fhz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fhz OCA], [http://pdbe.org/5fhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fhz RCSB], [http://www.ebi.ac.uk/pdbsum/5fhz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fhz ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN]] Isolated anophthalmia - microphthalmia. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN] Isolated anophthalmia - microphthalmia. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN]] Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
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[https://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN] Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Garavaglia, S]]
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[[Category: Garavaglia S]]
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[[Category: Moretti, A]]
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[[Category: Moretti A]]
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[[Category: Rizzi, M]]
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[[Category: Rizzi M]]
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[[Category: Oxidoreductase]]
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[[Category: Product-bound structure]]
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[[Category: Retinaldehyde dehydrogenase]]
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[[Category: Tetramer]]
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Current revision

Human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid

PDB ID 5fhz

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