5fiq

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Current revision (06:52, 19 July 2023) (edit) (undo)
 
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<StructureSection load='5fiq' size='340' side='right'caption='[[5fiq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='5fiq' size='340' side='right'caption='[[5fiq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fiq]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Bommo Bommo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FIQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fiq]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FIQ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fis|5fis]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fiq OCA], [http://pdbe.org/5fiq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fiq RCSB], [http://www.ebi.ac.uk/pdbsum/5fiq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fiq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fiq OCA], [https://pdbe.org/5fiq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fiq RCSB], [https://www.ebi.ac.uk/pdbsum/5fiq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fiq ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EXD1_BOMMO EXD1_BOMMO] RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.<ref>PMID:26669262</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bommo]]
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[[Category: Bombyx mori]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, K M]]
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[[Category: Chen KM]]
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[[Category: Fauvarque, M O]]
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[[Category: Fauvarque MO]]
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[[Category: Homolka, D]]
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[[Category: Homolka D]]
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[[Category: Janeiro, B K.Rodino]]
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[[Category: McCarthy AA]]
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[[Category: McCarthy, A A]]
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[[Category: Pandey RR]]
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[[Category: Pandey, R R]]
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[[Category: Pillai RS]]
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[[Category: Pillai, R S]]
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[[Category: Reuter M]]
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[[Category: Reuter, M]]
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[[Category: Rodino Janeiro BK]]
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[[Category: Sachidanandam, R]]
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[[Category: Sachidanandam R]]
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[[Category: Yang, Z]]
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[[Category: Yang Z]]
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[[Category: Dimer]]
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[[Category: Exonuclease]]
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[[Category: Hydrolase]]
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[[Category: Pirna biogenesis]]
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[[Category: Rna binding]]
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Current revision

Exonuclease domain-containing 1 (Exd1) in the native conformation

PDB ID 5fiq

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