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5fiy

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<StructureSection load='5fiy' size='340' side='right'caption='[[5fiy]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='5fiy' size='340' side='right'caption='[[5fiy]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fiy]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FIY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fiy]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FIY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fiy OCA], [http://pdbe.org/5fiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fiy RCSB], [http://www.ebi.ac.uk/pdbsum/5fiy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fiy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fiy OCA], [https://pdbe.org/5fiy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fiy RCSB], [https://www.ebi.ac.uk/pdbsum/5fiy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fiy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAWR_RAT PAWR_RAT]] Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity).
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[https://www.uniprot.org/uniprot/PAWR_RAT PAWR_RAT] Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Eidhoff, U B]]
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[[Category: Rattus norvegicus]]
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[[Category: Kubicek, J]]
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[[Category: Eidhoff UB]]
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[[Category: Labahn, J]]
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[[Category: Kubicek J]]
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[[Category: Subhramanyam, U K.Tiruttani]]
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[[Category: Labahn J]]
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[[Category: Apoptosis]]
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[[Category: Tiruttani Subhramanyam UK]]

Current revision

crystal structure of coiled coil domain of PAWR

PDB ID 5fiy

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