Nucleoside triphosphatase

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<SX viewer='molstar' load='' size='323' side='right' caption='NTPase 2 tetramer complex with AMPPNP and Mg++ ion (green) (PDB code [[4a5a]]).' scene='84/844927/Cv1/2' >
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<StructureSection load='4a5a' size='350' side='right' caption='NTPase 2 tetramer complex with AMPPNP and Mg++ ion (green) (PDB entry [[4a5a]])' scene=''>
== Function ==
== Function ==
'''Nucleoside triphosphatase''' or '''nucleoside triphosphate diphosphohydrolase''' (NTPase) is responsible for degradation of nucleotides to their monophosphate form. NTPase is found in mammals and in pathogenic microbes. In mammals NTPase hs a crucial role in regulation of purinergic signalling by hydrolysis of extracellular nucleotides. The function of NTPase in pathogens is still unknown<ref>PMID:24115522</ref>.
'''Nucleoside triphosphatase''' or '''nucleoside triphosphate diphosphohydrolase''' (NTPase) is responsible for degradation of nucleotides to their monophosphate form. NTPase is found in mammals and in pathogenic microbes. In mammals NTPase hs a crucial role in regulation of purinergic signalling by hydrolysis of extracellular nucleotides. The function of NTPase in pathogens is still unknown<ref>PMID:24115522</ref>.
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*'''Nucleoside triphosphatase Nudi''' catalyses the hydrolysis of preferentially dUTP, dTTP and dCTP.
== Relevance ==
== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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''Toxoplasma gondii'' <snapshot name='84/844927/Cv1/1'>NTPase 2 is dimer of dimers</snapshot> (PDB code [[4a5a]]). The 3D structure of the complex between NTPase 2 and the ATP analog AMPPNP shows the NTPase structure composed of two domains. Domain I contains the N-terminal and C-terminal and domain II the core residues. The structure contains 7 Cys-Cys bonds one of which located between domain I and II and reaching the diametrically positioned monomer was found by mutational analysis to be responsible for activation. The ATP analog - AMPPNP - is located in a cleft and forms interactions with domain I and domain II<ref>PMID:22130673</ref>.
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''Toxoplasma gondii'' <snapshot name='84/844927/Cv1/3'>NTPase 2 is dimer of dimers</snapshot> (PDB code [[4a5a]]). The 3D structure of the complex between NTPase 2 and the ATP analog AMPPNP shows the NTPase structure composed of two domains. Domain I contains the N-terminal and C-terminal and domain II the core residues. The structure contains 7 Cys-Cys bonds one of which located between domain I and II and reaching the diametrically positioned monomer was found by mutational analysis to be responsible for activation. The ATP analog - AMPPNP - is located in a cleft and forms interactions with domain I and domain II<ref>PMID:22130673</ref>.
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*<snapshot name='84/844927/Cv1/5'>Test1</snapshot>
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</SX>
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*<snapshot name='84/844927/Cv1/6'>Test2</snapshot>
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*<snapshot name='84/844927/Cv1/8'>Test3</snapshot>
==3D structures of nucleoside triphosphatase==
==3D structures of nucleoside triphosphatase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Nucleoside triphosphatase 3D structures]]
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Nucleoside triphosphatase 1
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**[[4a57]] - TgNTPase 1 - ''Toxoplasma gondii'' <br />
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**[[4a59]] - TgNTPase 1 + AMP<br />
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*Nucleoside triphosphatase 2
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**[[4jep]] - TgNTPase 2 <br />
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**[[4a5b]] - TgNTPase 2 (mutant)<br />
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**[[4kh4]], [[4a5a]] - TgNTPase 2 (mutant) + AMPPNP<br />
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**[[4kh5]], [[4kh6]] - TgNTPase 2 (mutant) + AMPNP<br />
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*Nucleoside triphosphatase Nudi
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**[[6dt3]] - Nudi - ''Klebsiella pneumoniae'' <br />
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**[[3oga]], [[3n77]] - Nudi - ''Salmonella enterica'' <br />
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*Nucleoside triphosphatase cancer-related
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**[[2i3b]] - NTPase - human- NMR <br />
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*Nucleoside triphosphatase
 
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**[[3s86]] - NTPase - ''Thermotoga maritima'' <br />
 
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**[[3agr]] - NTPase - ''Neospora caninum'' <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

NTPase 2 tetramer complex with AMPPNP and Mg++ ion (green) (PDB entry 4a5a)

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Alexander Berchansky, Michal Harel, Joel L. Sussman

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