6vw4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:21, 11 October 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6vw4 is ON HOLD until Paper Publication
+
==2.35 Angstrom structure of Caci_6494 from Catenulispora Acidiphila in complex with S-DNPA==
 +
<StructureSection load='6vw4' size='340' side='right'caption='[[6vw4]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[6vw4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Catenulispora_acidiphila_DSM_44928 Catenulispora acidiphila DSM 44928]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VW4 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SDN:[(3S)-9-HYDROXY-1-METHYL-10-OXO-4,10-DIHYDRO-3H-BENZO[G]ISOCHROMEN-3-YL]ACETIC+ACID'>SDN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vw4 OCA], [https://pdbe.org/6vw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vw4 RCSB], [https://www.ebi.ac.uk/pdbsum/6vw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vw4 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/C7PWR4_CATAD C7PWR4_CATAD]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Proteins belonging to the NTF2-like superfamily are present in the biosynthetic pathways of numerous polyketide natural products, such as anthracyclins and benzoisochromanequinones. Some have been found to be bona fide polyketide cyclases, but many of them have roles that are currently unknown. Here, the X-ray crystal structures of three NTF2-like proteins of unknown function are reported: those of ActVI-ORFA from Streptomyces coelicolor A3(2) and its homologs Caci_6494, a protein from an uncharacterized biosynthetic cluster in Catenulispora acidiphila, and Aln2 from Streptomyces sp. CM020, a protein in the biosynthetic pathway of alnumycin. The presence of a solvent-accessible cavity and the conservation of the His/Asp dyad that is characteristic of many polyketide cyclases suggest a potential enzymatic role for these enzymes in polyketide biosynthesis.
-
Authors: Vuksanovic, N., Silvaggi, N.
+
Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis.,Vuksanovic N, Zhu X, Serrano DA, Siitonen V, Metsa-Ketela M, Melancon CE 3rd, Silvaggi NR Acta Crystallogr F Struct Biol Commun. 2020 Aug 1;76(Pt 8):372-383. doi:, 10.1107/S2053230X20009814. Epub 2020 Jul 29. PMID:32744249<ref>PMID:32744249</ref>
-
Description: 2.35 Angstrom structure of Caci_6494 from Catenulispora Acidiphila in complex with S-DNPA
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Unreleased Structures]]
+
</div>
-
[[Category: Vuksanovic, N]]
+
<div class="pdbe-citations 6vw4" style="background-color:#fffaf0;"></div>
-
[[Category: Silvaggi, N]]
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Catenulispora acidiphila DSM 44928]]
 +
[[Category: Large Structures]]
 +
[[Category: Silvaggi NR]]
 +
[[Category: Vuksanovic N]]

Current revision

2.35 Angstrom structure of Caci_6494 from Catenulispora Acidiphila in complex with S-DNPA

PDB ID 6vw4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools