6tn9

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==X-RAY STRUCTURE OF MPS1 IN COMPLEX WITH COMPOUND 16==
==X-RAY STRUCTURE OF MPS1 IN COMPLEX WITH COMPOUND 16==
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<StructureSection load='6tn9' size='340' side='right'caption='[[6tn9]]' scene=''>
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<StructureSection load='6tn9' size='340' side='right'caption='[[6tn9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TN9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TN9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6tn9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TN9 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tn9 OCA], [http://pdbe.org/6tn9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tn9 RCSB], [http://www.ebi.ac.uk/pdbsum/6tn9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tn9 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NN5:[4-[[6-(3,5-dimethyl-4-oxidanyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]-morpholin-4-yl-methanone'>NN5</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tn9 OCA], [https://pdbe.org/6tn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tn9 RCSB], [https://www.ebi.ac.uk/pdbsum/6tn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tn9 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
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==See Also==
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*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bader B]]
[[Category: Bader B]]

Current revision

X-RAY STRUCTURE OF MPS1 IN COMPLEX WITH COMPOUND 16

PDB ID 6tn9

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