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6t79

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Current revision (10:17, 22 May 2024) (edit) (undo)
 
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<StructureSection load='6t79' size='340' side='right'caption='[[6t79]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='6t79' size='340' side='right'caption='[[6t79]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6t79]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T79 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T79 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6t79]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T79 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6t7a|6t7a]], [[6t7b|6t7b]], [[6t7c|6t7c]], [[6t7d|6t7d]], [[6t78|6t78]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HIST2H3A, HIST2H3C, H3F2, H3FM, HIST2H3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2AB, H2AFM, HIST1H2AE, H2AFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HIST1H2BK, H2BFT, HIRIP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t79 OCA], [https://pdbe.org/6t79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t79 RCSB], [https://www.ebi.ac.uk/pdbsum/6t79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t79 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t79 OCA], [http://pdbe.org/6t79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t79 RCSB], [http://www.ebi.ac.uk/pdbsum/6t79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t79 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/H2B1K_HUMAN H2B1K_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
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[https://www.uniprot.org/uniprot/H32_HUMAN H32_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6t79" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6t79" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cramer, P]]
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[[Category: Synthetic construct]]
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[[Category: Dienemann, C]]
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[[Category: Cramer P]]
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[[Category: Dodonova, S O]]
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[[Category: Dienemann C]]
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[[Category: Taipale, J]]
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[[Category: Dodonova SO]]
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[[Category: Zhu, F]]
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[[Category: Taipale J]]
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[[Category: Dna]]
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[[Category: Zhu F]]
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[[Category: Histone]]
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[[Category: Nuclear protein]]
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[[Category: Nucleosome]]
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Current revision

Structure of a human nucleosome at 3.2 A resolution

PDB ID 6t79

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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