2lyg

<StructureSection load='2lyg' size='340' side='right'caption='[[2lyg]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2lyg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LYG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2LYG FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CF:2-HYDROXYETHYL+6-DEOXY-BETA-L-GALACTOPYRANOSIDE'>1CF</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2lyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lyg OCA], [http://pdbe.org/2lyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lyg RCSB], [http://www.ebi.ac.uk/pdbsum/2lyg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lyg ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, supramolecular chemistry to nanoscience. We have prepared carbohydrate-DNA conjugates containing the oligonucleotide sequences of G-quadruplexes (thrombin binding aptamer (TBA) and human telomere (TEL)), measured their thermal stability and studied their structure in solution by using NMR and molecular dynamics. The solution structure of a fucose-TBA conjugate shows stacking interactions between the carbohydrate and the DNA G-tetrad in addition to hydrogen bonding and hydrophobic contacts. We have also shown that attaching carbohydrates at the 5'-end of a quadruplex telomeric sequence can alter its folding topology. These results suggest the possibility of modulating the folding of the G-quadruplex by linking carbohydrates and have clear implications in molecular recognition and the design of new G-quadruplex ligands.

Carbohydrate-DNA interactions at G-quadruplexes: folding and stability changes by attaching sugars at the 5'-end.,Gomez-Pinto I, Vengut-Climent E, Lucas R, Avino A, Eritja R, Gonzalez C, Morales JC Chemistry. 2013 Feb 4;19(6):1920-7. doi: 10.1002/chem.201203902. Epub 2013 Jan, 11. PMID:23315826<ref>PMID:23315826</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2lyg" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Avio, A]]

[[Category: Eritja, R]]

[[Category: Gomez-Pinto, I]]

[[Category: Gonzalez-Ibaez, C]]

[[Category: Lucas, R]]

[[Category: Morales, J]]

[[Category: Vengut-Climent, E]]

[[Category: G-quadruplex structure]]