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5ghe

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<StructureSection load='5ghe' size='340' side='right'caption='[[5ghe]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5ghe' size='340' side='right'caption='[[5ghe]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ghe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._thuringiensis"_smith_et_al._1952 "bacillus cereus var. thuringiensis" smith et al. 1952]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GHE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GHE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ghe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GHE FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cry6Aa, cryVIa, cryVIA(a) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1428 "Bacillus cereus var. thuringiensis" Smith et al. 1952])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.901&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ghe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ghe OCA], [http://pdbe.org/5ghe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ghe RCSB], [http://www.ebi.ac.uk/pdbsum/5ghe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ghe ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ghe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ghe OCA], [https://pdbe.org/5ghe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ghe RCSB], [https://www.ebi.ac.uk/pdbsum/5ghe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ghe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CR6AA_BACTU CR6AA_BACTU]] Endotoxin with nematicidal activity.
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[https://www.uniprot.org/uniprot/CR6AA_BACTU CR6AA_BACTU] Endotoxin with nematicidal activity.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Crystal (Cry) proteins from Bacillus thuringiensis (Bt) are globally used in agriculture as proteinaceous insecticides. Numerous crystal structures have been determined, and most exhibit conserved three-dimensional architectures. Recently, we have identified a novel nematicidal mechanism by which Cry6Aa triggers cell death through a necrosis-signaling pathway via an interaction with the host protease ASP-1. However, we found little sequence conservation of Cry6Aa in our functional study. Here, we report the 1.90 angstrom (A) resolution structure of the proteolytic form of Cry6Aa (1-396), determined by X-ray crystallography. The structure of Cry6Aa is highly similar to those of the pathogenic toxin family of ClyA-type alpha-pore-forming toxins (alpha-PFTs), which are characterized by a bipartite structure comprising a head domain and a tail domain, thus suggesting that Cry6Aa exhibits a previously undescribed nematicidal mode of action. This structure also provides a framework for the functional study of other nematicidal toxins.
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Crystal structure of Cry6Aa: A novel nematicidal ClyA-type alpha-pore-forming toxin from Bacillus thuringiensis.,Huang J, Guan Z, Wan L, Zou T, Sun M Biochem Biophys Res Commun. 2016 Jul 2. pii: S0006-291X(16)31118-4. doi:, 10.1016/j.bbrc.2016.07.002. PMID:27381865<ref>PMID:27381865</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5ghe" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Delta-endotoxin|Delta-endotoxin]]
*[[Delta-endotoxin|Delta-endotoxin]]
*[[Pesticidal crystal protein|Pesticidal crystal protein]]
*[[Pesticidal crystal protein|Pesticidal crystal protein]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus cereus var. thuringiensis smith et al. 1952]]
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[[Category: Bacillus thuringiensis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Guan, Z]]
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[[Category: Guan Z]]
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[[Category: Huang, J]]
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[[Category: Huang J]]
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[[Category: Sun, M]]
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[[Category: Sun M]]
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[[Category: Yin, P]]
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[[Category: Yin P]]
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[[Category: Zou, T]]
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[[Category: Zou T]]
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[[Category: Bacillus thuringiensis]]
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[[Category: Clya-type]]
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[[Category: Cry6aa2]]
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[[Category: Toxin]]
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Current revision

Crystal Structure of Bacillus thuringiensis Cry6Aa2 Protoxin

PDB ID 5ghe

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