This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Nerve growth factor
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref...) |
|||
| (11 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | + | <StructureSection load='1www' size='340' side='right' caption='Human NGF (green, yellowgreen) complex with TrkA receptor domain 5 (cyan, deepskyblue) (PDB code [[1www]])' scene='84/845929/Cv/1'> | |
| - | <StructureSection load=' | + | |
| - | + | ||
== Function == | == Function == | ||
| - | + | '''Nerve growth factor''' (NGF) belongs to the family of neurotrophins. NGF promotes survival and differentiation of sensory and sympathetic neurons. NGF signaling furthers neuroprotective and repair functions<ref>PMID:11520933</ref>. NGF interacts with 2 transmembrane receptors - TrkA and p75. | |
== Relevance == | == Relevance == | ||
| + | |||
| + | Increased cerebrospinal fluid levels of proNGF mark the onset of mild cognitive impairment and the transition to Alzheimer disease suggest that NGF is a potential Alzheimer biomarker<ref>PMID:31312116</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| + | The 3D structure of the complex between human NGF and one of its receptors - TrkA - shows the <scene name='84/845929/Cv/4'>receptor D-5 domain Ig-like structure</scene> flanking the <scene name='84/845929/Cv/5'>NGF homodimer</scene>. Various side chains form the <scene name='84/845929/Cv/10'>interactions between NGF and its receptor</scene> with a <scene name='84/845929/Cv/11'>totally buried NGF Arg residue forming the strongest one</scene><ref>PMID:10490030</ref>. Water molecules are shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
| Line 16: | Line 17: | ||
==3D structures of nerve growth factor== | ==3D structures of nerve growth factor== | ||
| - | [[4edk]], [[4edw]], [[5jz7]] - hβ-NGF + antibody | + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} |
| + | |||
| + | [[6yw8]] - hβ-NGF – human - NMR<br /> | ||
| + | [[4edk]], [[4edw]], [[5jz7]] - hβ-NGF + antibody<br /> | ||
[[2ifg]], [[1www]] - hβ-NGF + TrkA<br /> | [[2ifg]], [[1www]] - hβ-NGF + TrkA<br /> | ||
[[1sg1]] - hβ-NGF + neutrophin receptor<br /> | [[1sg1]] - hβ-NGF + neutrophin receptor<br /> | ||
| Line 22: | Line 26: | ||
[[6xuo]] - NGF - horse<br /> | [[6xuo]] - NGF - horse<br /> | ||
[[1btg]], [[5lsd]], [[1sgf]], [[1bet]] - mNGF - mouse<br /> | [[1btg]], [[5lsd]], [[1sgf]], [[1bet]] - mNGF - mouse<br /> | ||
| - | [[4xpj]] - mNGF + | + | [[4xpj]], [[4eax]] - mNGF + lipid<br /> |
| - | [[4ec7]] - NGF - cobra<br /> | + | [[6ffy]] - mNGF + SorCS2<br /> |
| + | [[3ij2]] - mNGF + TNFR<br /> | ||
| + | [[4ec7]] - NGF + lipid - cobra<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
3D structures of nerve growth factor
Updated on 17-November-2021
6yw8 - hβ-NGF – human - NMR
4edk, 4edw, 5jz7 - hβ-NGF + antibody
2ifg, 1www - hβ-NGF + TrkA
1sg1 - hβ-NGF + neutrophin receptor
4zbn - hβ-NGF + DNA
6xuo - NGF - horse
1btg, 5lsd, 1sgf, 1bet - mNGF - mouse
4xpj, 4eax - mNGF + lipid
6ffy - mNGF + SorCS2
3ij2 - mNGF + TNFR
4ec7 - NGF + lipid - cobra
References
- ↑ Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001;24:1217-81. doi: 10.1146/annurev.neuro.24.1.1217. PMID:11520933 doi:http://dx.doi.org/10.1146/annurev.neuro.24.1.1217
- ↑ Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD. Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease. Front Neurosci. 2019 Jul 1;13:533. doi: 10.3389/fnins.2019.00533. eCollection, 2019. PMID:31312116 doi:http://dx.doi.org/10.3389/fnins.2019.00533
- ↑ Wiesmann C, Ultsch MH, Bass SH, de Vos AM. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 1999 Sep 9;401(6749):184-8. PMID:10490030 doi:10.1038/43705
