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Factor IXa
From Proteopedia
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==Structure== | ==Structure== | ||
<StructureSection load='6mv4' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='6mv4' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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The crystal structure of Factor IXa complexed with p-amino-benzamidine.<ref>PMID:30725510</ref> | The crystal structure of Factor IXa complexed with p-amino-benzamidine.<ref>PMID:30725510</ref> | ||
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | + | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. |
| - | The catalytic triad at the active site is comprised of | + | Here is an <scene name='84/845969/Cat_triad_over/1'>Overview of the Catalytic Triad</scene>The catalytic triad at the active site is comprised of His57, Asp102 and Ser1985 is highlighted. Now <scene name='84/845969/Cat_triad_zoom/1'>Zoom in on the Catalytic Triad</scene>. The His borrows an H from Her, which now attacks at the substrate. In this case the active site is blocked by the inhibitor, p-amino-benzamidine. |
Mutation of C252S results in Hemophilia B, probably due to destabilization of the loop including the His of the catalytic triad. | Mutation of C252S results in Hemophilia B, probably due to destabilization of the loop including the His of the catalytic triad. | ||
A mutation of T194A exhibits increased activity and stability and appears to enhance the risk for Deep Vein Thrombosis and stroke. | A mutation of T194A exhibits increased activity and stability and appears to enhance the risk for Deep Vein Thrombosis and stroke. | ||
Current revision
Structure
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References
- ↑ Vadivel K, Schreuder HA, Liesum A, Schmidt AE, Goldsmith G, Bajaj SP. Sodium-site in serine protease domain of human coagulation factor IXa: evidence from the crystal structure and molecular dynamics simulations study. J Thromb Haemost. 2019 Feb 6. doi: 10.1111/jth.14401. PMID:30725510 doi:http://dx.doi.org/10.1111/jth.14401
