7c3m

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m (Protected "7c3m" [edit=sysop:move=sysop])
Current revision (10:50, 27 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7c3m is ON HOLD
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==Structure of FERM protein==
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<StructureSection load='7c3m' size='340' side='right'caption='[[7c3m]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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Authors: Bu, W., Loh, Z.Y., Jin, S., Basu, S., Ero, R., Park, J.E., Yan, X., Wang, M., Sze, S.K., Tan, S.M., Gao, Y.G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7c3m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C3M FirstGlance]. <br>
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Description: structure of FERM protein
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c3m OCA], [https://pdbe.org/7c3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c3m RCSB], [https://www.ebi.ac.uk/pdbsum/7c3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c3m ProSAT]</span></td></tr>
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[[Category: Wang, M]]
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</table>
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[[Category: Gao, Y.G]]
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== Disease ==
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[[Category: Park, J.E]]
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[https://www.uniprot.org/uniprot/URP2_HUMAN URP2_HUMAN] Leukocyte adhesion deficiency type III. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:19064721</ref> <ref>PMID:19234463</ref> <ref>PMID:19234460</ref> <ref>PMID:18779414</ref> <ref>PMID:19617577</ref>
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[[Category: Basu, S]]
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== Function ==
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[[Category: Yan, X]]
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[https://www.uniprot.org/uniprot/URP2_HUMAN URP2_HUMAN] Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).<ref>PMID:18280249</ref> <ref>PMID:19064721</ref> <ref>PMID:19234463</ref> <ref>PMID:19234460</ref> Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.<ref>PMID:18280249</ref> <ref>PMID:19064721</ref> <ref>PMID:19234463</ref> <ref>PMID:19234460</ref>
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[[Category: Jin, S]]
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== References ==
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[[Category: Loh, Z.Y]]
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<references/>
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[[Category: Tan, S.M]]
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__TOC__
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[[Category: Sze, S.K]]
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</StructureSection>
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[[Category: Ero, R]]
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[[Category: Homo sapiens]]
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[[Category: Bu, W]]
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[[Category: Large Structures]]
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[[Category: Basu S]]
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[[Category: Bu W]]
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[[Category: Ero R]]
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[[Category: Gao YG]]
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[[Category: Jin S]]
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[[Category: Loh ZY]]
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[[Category: Park JE]]
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[[Category: Sze SK]]
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[[Category: Tan SM]]
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[[Category: Wang M]]
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[[Category: Yan X]]

Current revision

Structure of FERM protein

PDB ID 7c3m

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OCA

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